Comput Methods Programs Biomed - Segmentation of cervical cell nuclei in high-resolution microscopic images: A new algorithm and a web-based software framework.

Tópicos

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Resumo

In order to automate cervical cancer screening tests, one of the most important and longstanding challenges is the segmentation of cell nuclei in the stained specimens. Though nuclei of isolated cells in high-quality acquisitions often are easy to segment, the problem lies in the segmentation of large numbers of nuclei with various characteristics under differing acquisition conditions in high-resolution scans of the complete microscope slides. We implemented a system that enables processing of full resolution images, and proposes a new algorithm for segmenting the nuclei under adequate control of the expert user. The system can work automatically or interactively guided, to allow for segmentation within the whole range of slide and image characteristics. It facilitates data storage and interaction of technical and medical experts, especially with its web-based architecture. The proposed algorithm localizes cell nuclei using a voting scheme and prior knowledge, before it determines the exact shape of the nuclei by means of an elastic segmentation algorithm. After noise removal with a mean-shift and a median filtering takes place, edges are extracted with a Canny edge detection algorithm. Motivated by the observation that cell nuclei are surrounded by cytoplasm and their shape is roughly elliptical, edges adjacent to the background are removed. A randomized Hough transform for ellipses finds candidate nuclei, which are then processed by a level set algorithm. The algorithm is tested and compared to other algorithms on a database containing 207 images acquired from two different microscope slides, with promising results.

Resumo Limpo

order autom cervic cancer screen test one import longstand challeng segment cell nuclei stain specimen though nuclei isol cell highqual acquisit often easi segment problem lie segment larg number nuclei various characterist differ acquisit condit highresolut scan complet microscop slide implement system enabl process full resolut imag propos new algorithm segment nuclei adequ control expert user system can work automat interact guid allow segment within whole rang slide imag characterist facilit data storag interact technic medic expert especi webbas architectur propos algorithm local cell nuclei use vote scheme prior knowledg determin exact shape nuclei mean elast segment algorithm nois remov meanshift median filter take place edg extract canni edg detect algorithm motiv observ cell nuclei surround cytoplasm shape rough ellipt edg adjac background remov random hough transform ellips find candid nuclei process level set algorithm algorithm test compar algorithm databas contain imag acquir two differ microscop slide promis result

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