Comput Methods Programs Biomed - Bayesian sample-size determination for two independent Poisson rates.

Tópicos

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{ age(1611) year(1155) adult(843) }
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{ signal(2180) analysi(812) frequenc(800) }
{ gene(2352) biolog(1181) express(1162) }
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Resumo

Because of the high cost and time constraints for clinical trials, researchers often need to determine the smallest sample size that provides accurate inferences for a parameter of interest. Although most experimenters have employed frequentist sample-size determination methods, the Bayesian paradigm offers a wide variety of sample-size determination methodologies. Bayesian sample-size determination methods are becoming increasingly more popular in clinical trials because of their flexibility and easy interpretation inferences. Recently, Bayesian approaches have been used to determine the sample size of a single Poisson rate parameter in a clinical trial setting. In this paper, we extend these results to the comparison of two Poisson rates and develop methods for sample-size determination for hypothesis testing in a Bayesian context. We have created functions in R to determine the parameters for the conjugate gamma prior and calculate the sample size for the average length criterion and average power methods. We also provide two examples that implement our sample-size determination methods using clinical data.

Resumo Limpo

high cost time constraint clinic trial research often need determin smallest sampl size provid accur infer paramet interest although experiment employ frequentist samples determin method bayesian paradigm offer wide varieti samples determin methodolog bayesian samples determin method becom increas popular clinic trial flexibl easi interpret infer recent bayesian approach use determin sampl size singl poisson rate paramet clinic trial set paper extend result comparison two poisson rate develop method samples determin hypothesi test bayesian context creat function r determin paramet conjug gamma prior calcul sampl size averag length criterion averag power method also provid two exampl implement samples determin method use clinic data

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