Comput Methods Programs Biomed - Kinetic modelling of haemodialysis removal of myoglobin in rhabdomyolysis patients.

Tópicos

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Resumo

An extended two compartment model is proposed to describe the dynamics of myoglobin in rhabdomyolysis patients undergoing dialysis. Before using clinical data to estimate the model's unknown parameters, structural identifiability analysis was performed to determine the parameters uniqueness given certain clinical observations. A Taylor series expansion method was implemented which found that the model was structurally globally/uniquely identifiable for both on- and off-dialysis phases. The fitted model was then used in a predictive capacity showing that the use of Theralite high cut-off (HCO) or HCO 1100 dialyser gave a significant reduction in myoglobin renal exposure compared to standard haemodialysis (HD).

Resumo Limpo

extend two compart model propos describ dynam myoglobin rhabdomyolysi patient undergo dialysi use clinic data estim model unknown paramet structur identifi analysi perform determin paramet uniqu given certain clinic observ taylor seri expans method implement found model structur globallyuniqu identifi offdialysi phase fit model use predict capac show use theralit high cutoff hco hco dialys gave signific reduct myoglobin renal exposur compar standard haemodialysi hd

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