Comput Methods Programs Biomed - Glucose-insulin regulation model with subcutaneous insulin injection and evaluation using diabetic inpatients data.

Tópicos

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Resumo

Closed-loop insulin delivery systems often implement glucose measurement and insulin administration in the subcutis. However some existing models for glucose-insulin system ignored the dynamics of subcutaneous glucose and subcutaneously-injected insulin. This paper reports a two-compartment model that includes glucose and insulin dynamics in subcutis, and its evaluation using patient data. Clinical information such as glucose level, insulin dosage, insulin injection time and meals of anonymous diabetes inpatients was collected. Measured glucose level of the diabetic inpatients agrees with that of computer simulation. Due to the lack of glucose-insulin model with subcutaneously-injected insulin for type 2 diabetic patients, our model was compared with existing model for type 1 subjects. The new glucose-insulin model can mimic dynamics of glucose and insulin under the disturbance of insulin injections and meals. Model parameters were estimated using nonlinear least square method and their effect on pathology and physiology of diabetes were analyzed.

Resumo Limpo

closedloop insulin deliveri system often implement glucos measur insulin administr subcuti howev exist model glucoseinsulin system ignor dynam subcutan glucos subcutaneouslyinject insulin paper report twocompart model includ glucos insulin dynam subcuti evalu use patient data clinic inform glucos level insulin dosag insulin inject time meal anonym diabet inpati collect measur glucos level diabet inpati agre comput simul due lack glucoseinsulin model subcutaneouslyinject insulin type diabet patient model compar exist model type subject new glucoseinsulin model can mimic dynam glucos insulin disturb insulin inject meal model paramet estim use nonlinear least squar method effect patholog physiolog diabet analyz

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