Comput Methods Programs Biomed - Validation study of a fast, accurate, and precise brain tumor volume measurement.

Tópicos

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Resumo

LABELLED: Precision and accuracy are sometimes sacrificed to ensure that medical image processing is rapid. To address this, our lab had developed a novel level set segmentation algorithm that is 16? faster and >96% accurate on realistic brain phantoms.METHODS: This study reports speed, precision and estimated accuracy of our algorithm when measuring MRIs of meningioma brain tumors and compares it to manual tracing and modified MacDonald (MM) ellipsoid criteria. A repeated-measures study allowed us to determine measurement precisions (MPs) - clinically relevant thresholds for statistically significant change.RESULTS: Speed: the level set, MM, and trace methods required 1:20, 1:35, and 9:35 (mm:ss) respectively on average to complete a volume measurement (p<0.05). Accuracy: the level set was not statistically different to the estimated true lesion volumes (p>0.05). Precision: the MM's within-operator and between-operator MPs were significantly higher (worse) than the other methods (p<0.05). The observed difference in MP between the level set and trace methods did not reach statistical significance (p>0.05).CONCLUSION: Our level set is faster on average than MM, yet has accuracy and precision comparable to manual tracing.

Resumo Limpo

label precis accuraci sometim sacrif ensur medic imag process rapid address lab develop novel level set segment algorithm faster accur realist brain phantomsmethod studi report speed precis estim accuraci algorithm measur mris meningioma brain tumor compar manual trace modifi macdonald mm ellipsoid criteria repeatedmeasur studi allow us determin measur precis mps clinic relev threshold statist signific changeresult speed level set mm trace method requir mmss respect averag complet volum measur p accuraci level set statist differ estim true lesion volum p precis mms withinoper betweenoper mps signific higher wors method p observ differ mp level set trace method reach statist signific pconclus level set faster averag mm yet accuraci precis compar manual trace

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