Comput Methods Programs Biomed - In silico study of the haemodynamic effects induced by mechanical ventilation and biventricular pacemaker.

Tópicos

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Resumo

In silico modeling of the cardiovascular system (CVS) can help both in understanding pharmacological or pathophysiological process and in providing information which could not be obtained by means of traditional clinical research methods due to practical or ethical reasons. In this work the numerical CVS was used to study the effect of interaction between mechanical ventilation and biventricular pacemaker by haemodynamic and energetic point of view. Starting from literature data on patients with intra and/or inter-ventricular activation time delay and treated using biventricular pacemaker, we used in silico simulator to analyse the effects induced by mechanical ventilatory assistance (MVA). After reproducing baseline and CRT conditions, the MVA was simulated changing the mean intrathoracic pressure value. Results show that simultaneous application of CRT and MVA yields a reduction of cardiac output, left ventricular end-diastolic and end-systolic volume when positive mean intrathoracic pressure is applied. In the same conditions, when MVA is applied, left ventricular ejection fraction, mean left (right) atrial and pulmonary arterial pressure increase.

Resumo Limpo

silico model cardiovascular system cvs can help understand pharmacolog pathophysiolog process provid inform obtain mean tradit clinic research method due practic ethic reason work numer cvs use studi effect interact mechan ventil biventricular pacemak haemodynam energet point view start literatur data patient intra andor interventricular activ time delay treat use biventricular pacemak use silico simul analys effect induc mechan ventilatori assist mva reproduc baselin crt condit mva simul chang mean intrathorac pressur valu result show simultan applic crt mva yield reduct cardiac output left ventricular enddiastol endsystol volum posit mean intrathorac pressur appli condit mva appli left ventricular eject fraction mean left right atrial pulmonari arteri pressur increas

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