AMIA Annu Symp Proc - Inter-rater agreement among physicians on the clinical significance of drug-drug interactions.

Tópicos

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Resumo

CKGROUND: Alert fatigue could potentially be improved if physicians agreed on which alerts were clinically significant. We conducted a study to determine the extent to which physicians agree on which drug-drug interactions are clinically significant.METHODS: Two groups of eight generalist physicians reviewed 100 randomly selected drug-drug interactions from the Medi-Span? Drug Therapy Monitoring System? database and indicated whether they thought each interaction was clinically significant based on the full-text clinical discussion contained within each interaction monograph and their clinical experience.RESULTS: The Fleiss Kappa measure of inter-rater agreement was 0.19 (0.12, 0.26) for one group, 0.22 (0.14, 0.29) for the second group and 0.21 (0.15, 0.27) for the combined group.CONCLUSION: We found poor agreement among generalist physicians on which drug-drug interactions are clinically significant. Use of a feature to allow physicians to tailor alerts to their needs may be an important component in reducing alert fatigue.

Resumo Limpo

ckground alert fatigu potenti improv physician agre alert clinic signific conduct studi determin extent physician agre drugdrug interact clinic significantmethod two group eight generalist physician review random select drugdrug interact medispan drug therapi monitor system databas indic whether thought interact clinic signific base fulltext clinic discuss contain within interact monograph clinic experienceresult fleiss kappa measur interrat agreement one group second group combin groupconclus found poor agreement among generalist physician drugdrug interact clinic signific use featur allow physician tailor alert need may import compon reduc alert fatigu

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