Comput Methods Programs Biomed - An FDTD-based computer simulation platform for shock wave propagation in electrohydraulic lithotripsy.


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Extracorporeal Shock Wave Lithotripsy (ESWL) is based on disintegration of the kidney stone by delivering high-energy shock waves that are created outside the body and transmitted through the skin and body tissues. Nowadays high-energy shock waves are also used in orthopedic operations and investigated to be used in the treatment of myocardial infarction and cancer. Because of these new application areas novel lithotriptor designs are needed for different kinds of treatment strategies. In this study our aim was to develop a versatile computer simulation environment which would give the device designers working on various medical applications that use shock wave principle a substantial amount of flexibility while testing the effects of new parameters such as reflector size, material properties of the medium, water temperature, and different clinical scenarios. For this purpose, we created a finite-difference time-domain (FDTD)-based computational model in which most of the physical system parameters were defined as an input and/or as a variable in the simulations. We constructed a realistic computational model of a commercial electrohydraulic lithotriptor and optimized our simulation program using the results that were obtained by the manufacturer in an experimental setup. We, then, compared the simulation results with the results from an experimental setup in which oxygen level in water was varied. Finally, we studied the effects of changing the input parameters like ellipsoid size and material, temperature change in the wave propagation media, and shock wave source point misalignment. The simulation results were consistent with the experimental results and expected effects of variation in physical parameters of the system. The results of this study encourage further investigation and provide adequate evidence that the numerical modeling of a shock wave therapy system is feasible and can provide a practical means to test novel ideas in new device design procedures.

Resumo Limpo

extracorpor shock wave lithotripsi eswl base disintegr kidney stone deliv highenergi shock wave creat outsid bodi transmit skin bodi tissu nowaday highenergi shock wave also use orthoped oper investig use treatment myocardi infarct cancer new applic area novel lithotriptor design need differ kind treatment strategi studi aim develop versatil comput simul environ give devic design work various medic applic use shock wave principl substanti amount flexibl test effect new paramet reflector size materi properti medium water temperatur differ clinic scenario purpos creat finitediffer timedomain fdtdbase comput model physic system paramet defin input andor variabl simul construct realist comput model commerci electrohydraul lithotriptor optim simul program use result obtain manufactur experiment setup compar simul result result experiment setup oxygen level water vari final studi effect chang input paramet like ellipsoid size materi temperatur chang wave propag media shock wave sourc point misalign simul result consist experiment result expect effect variat physic paramet system result studi encourag investig provid adequ evid numer model shock wave therapi system feasibl can provid practic mean test novel idea new devic design procedur

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