Comput Methods Programs Biomed - Using manual prostate contours to enhance deformable registration of endorectal MRI.

Tópicos

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Resumo

CKGROUND: Endorectal MRI provides detailed images of the prostate anatomy and is useful for radiation treatment planning. Here we describe a Demons field-initialized B-spline deformable registration of prostate MRI.MATERIAL AND METHODS: T2-weighted endorectal MRIs of five patients were used. The prostate and the tumor of each patient were manually contoured. The planning MRIs and their segmentations were simulated by warping the corresponding endorectal MRIs using thin plate spline (TPS). Deformable registration was initialized using the deformation field generated using Demons algorithm to map the deformed prostate MRI to the non-deformed one. The solution was refined with B-Spline registration. Volume overlap similarity was used to assess the accuracy of registration and to suggest a minimum margin to account for the registration errors.RESULTS: Initialization using Demons algorithm took about 15 min on a computer with 2.8 GHz Intel, 1.3 GB RAM. Refinement B-spline registration (200 iterations) took less than 5 min. Using the synthetic images as the ground truth, at zero margin, the average (S.D.) 98 (?0.4)% for prostate coverage was 97 (?1)% for tumor. The average (?S.D.) treatment margin required to cover the entire prostate was 1.5 (?0.2)mm. The average (? S.D.) treatment margin required to cover the tumor was 0.7 (?0.1)mm. We also demonstrated the challenges in registering an in vivo deformed MRI to an in vivo non-deformed MRI.DISCUSSION: We here present a deformable registration scheme that can overcome large deformation. This platform is expected to be useful for prostate cancer radiation treatment planning.

Resumo Limpo

ckground endorect mri provid detail imag prostat anatomi use radiat treatment plan describ demon fieldiniti bspline deform registr prostat mrimateri method tweight endorect mris five patient use prostat tumor patient manual contour plan mris segment simul warp correspond endorect mris use thin plate spline tps deform registr initi use deform field generat use demon algorithm map deform prostat mri nondeform one solut refin bspline registr volum overlap similar use assess accuraci registr suggest minimum margin account registr errorsresult initi use demon algorithm took min comput ghz intel gb ram refin bspline registr iter took less min use synthet imag ground truth zero margin averag sd prostat coverag tumor averag sd treatment margin requir cover entir prostat mm averag sd treatment margin requir cover tumor mm also demonstr challeng regist vivo deform mri vivo nondeform mridiscuss present deform registr scheme can overcom larg deform platform expect use prostat cancer radiat treatment plan

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