Comput Methods Programs Biomed - A geometrical approach for evaluating left ventricular remodeling in myocardial infarct patients.

Tópicos

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Resumo

A computational method for quantifying left ventricle (LV) remodeling using 3D mesh models reconstructed from magnetic resonance imaging is proposed. The underlying geometry of the LV mesh is obtained by using a quadric fitting method, and its quantification is performed by using a curvedness shape descriptor. To achieve robustness, we have performed detailed studies of the effects of n-ring parameter selection on the accuracy of this method with in vitro and in vivo LV models. We have found that curvedness calculations based on a 5-ring selection can accurately depict anomalies in LV shape despite the presence of noise due to manual image segmentation. Our studies show that patients after myocardial infarction exhibit significant LV shape alteration in terms of curvedness, in particular at the apex. The diastole-to-systole change in regional curvedness was significantly lower suggesting regional differences in hypokinesis due to infarcted myocardium. This approach may add new insights into ventricular deformation and enable better discrimination between normal and pathologic conditions.

Resumo Limpo

comput method quantifi left ventricl lv remodel use d mesh model reconstruct magnet reson imag propos under geometri lv mesh obtain use quadric fit method quantif perform use curved shape descriptor achiev robust perform detail studi effect nring paramet select accuraci method vitro vivo lv model found curved calcul base ring select can accur depict anomali lv shape despit presenc nois due manual imag segment studi show patient myocardi infarct exhibit signific lv shape alter term curved particular apex diastoletosystol chang region curved signific lower suggest region differ hypokinesi due infarct myocardium approach may add new insight ventricular deform enabl better discrimin normal patholog condit

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