Comput Methods Programs Biomed - Fractional order model parameters for the respiratory input impedance in healthy and in asthmatic children.

Tópicos

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Resumo

This paper provides an evaluation of a fractional order model for the respiratory input impedance, using two groups of subjects, respectively healthy and asthmatic children. The purpose is to verify if the model is able to deliver statistically meaningful parameter values in order to classify the two groups. The data are gathered with the non-invasive lung function test of forced oscillations technique, by means of a multisine signal within the 4-48Hz frequency range. Based on our previous work, a fractional order model for this range of frequencies is obtained. Additional parameters are proposed to evaluate the two groups. The results indicate that the model was unable to detect significant changes between the asthmatic children with normal spirometry results (as result of medication) and the healthy children. Due to medication intake during the hours prior to the exam, bronchial challenge did not modify substantially the respiratory parameters. Our findings correspond to similar studies reported in the specialized literature. Combined model parameters, such as the tissue damping and the tissue elastance were significantly different in the two groups (p<0.01). Two extra indexes are introduced: the quality factor and the power factor, providing significantly different results between the two groups (p?0.01). We conclude that the model can be used in the respective frequency range to characterize the two groups efficiently.

Resumo Limpo

paper provid evalu fraction order model respiratori input imped use two group subject respect healthi asthmat children purpos verifi model abl deliv statist meaning paramet valu order classifi two group data gather noninvas lung function test forc oscil techniqu mean multisin signal within hz frequenc rang base previous work fraction order model rang frequenc obtain addit paramet propos evalu two group result indic model unabl detect signific chang asthmat children normal spirometri result result medic healthi children due medic intak hour prior exam bronchial challeng modifi substanti respiratori paramet find correspond similar studi report special literatur combin model paramet tissu damp tissu elast signific differ two group p two extra index introduc qualiti factor power factor provid signific differ result two group p conclud model can use respect frequenc rang character two group effici

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