Comput Methods Programs Biomed - Waveform type evaluation in congenital nystagmus.

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Resumo

Congenital nystagmus is an ocular-motor disorder characterised by involuntary, conjugated and bilateral to and fro ocular oscillations. In this study a method to recognise automatically jerk waveform inside a congenital nystagmus recording and to compute foveation time and foveation position variability is presented. The recordings were performed with subjects looking at visual targets, presented in nine eye gaze positions; data were segmented into blocks corresponding to each gaze position. The nystagmus cycles were identified searching for local minima and maxima (SpEp sequence) in intervals centred on each slope change of the eye position signal (position criterion). The SpEp sequence was then refined using an adaptive threshold applied to the eye velocity signal; the outcome is a robust detection of each slow phase start point, fundamental to accurately compute some nystagmus parameters. A total of 1206 slow phases was used to compute the specificity in waveform recognition applying only the position criterion or adding the adaptive threshold; results showed an increase in negative predictive value of 25.1% using both features. The duration of each foveation window was measured on raw data or using an interpolating function of the congenital nystagmus slow phases; foveation time estimation less sensitive to noise was obtained in the second case.

Resumo Limpo

congenit nystagmus ocularmotor disord characteris involuntari conjug bilater fro ocular oscil studi method recognis automat jerk waveform insid congenit nystagmus record comput foveat time foveat posit variabl present record perform subject look visual target present nine eye gaze posit data segment block correspond gaze posit nystagmus cycl identifi search local minima maxima spep sequenc interv centr slope chang eye posit signal posit criterion spep sequenc refin use adapt threshold appli eye veloc signal outcom robust detect slow phase start point fundament accur comput nystagmus paramet total slow phase use comput specif waveform recognit appli posit criterion ad adapt threshold result show increas negat predict valu use featur durat foveat window measur raw data use interpol function congenit nystagmus slow phase foveat time estim less sensit nois obtain second case

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