Comput Methods Programs Biomed - Epithelial to mesenchymal transition-the roles of cell morphology, labile adhesion and junctional coupling.

Tópicos

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Resumo

Epithelial to mesenchymal transition (EMT) is a fundamental process during development and disease, including development of the heart valves and tumour metastases. An extended cellular Potts model was implemented to represent the behaviour emerging from autonomous cell morphology, labile adhesion, junctional coupling and cell motility. Computer simulations normally focus on these functional changes independently whereas this model facilitates exploration of the interplay between cell shape changes, adhesion and migration. The simulation model is fitted to an in vitro model of endocardial EMT, and agrees with the finding that Notch signalling increases cell-matrix adhesion in addition to modulating cell-cell adhesion.

Resumo Limpo

epitheli mesenchym transit emt fundament process develop diseas includ develop heart valv tumour metastas extend cellular pott model implement repres behaviour emerg autonom cell morpholog labil adhes junction coupl cell motil comput simul normal focus function chang independ wherea model facilit explor interplay cell shape chang adhes migrat simul model fit vitro model endocardi emt agre find notch signal increas cellmatrix adhes addit modul cellcel adhes

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