Comput Methods Programs Biomed - Texture analysis of poly-adenylated mRNA staining following global brain ischemia and reperfusion.

Tópicos

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Resumo

Texture analysis provides a means to quantify complex changes in microscope images. We previously showed that cytoplasmic poly-adenylated mRNAs form mRNA granules in post-ischemic neurons and that these granules correlated with protein synthesis inhibition and hence cell death. Here we utilized the texture analysis software MaZda to quantify mRNA granules in photomicrographs of the pyramidal cell layer of rat hippocampal region CA3 around 1h of reperfusion after 10min of normothermic global cerebral ischemia. At 1h reperfusion, we observed variations in the texture of mRNA granules amongst samples that were readily quantified by texture analysis. Individual sample variation was consistent with the interpretation that animal-to-animal variations in mRNA granules reflected the time-course of mRNA granule formation. We also used texture analysis to quantify the effect of cycloheximide, given either before or after brain ischemia, on mRNA granules. If administered before ischemia, cycloheximide inhibited mRNA granule formation, but if administered after ischemia did not prevent mRNA granulation, indicating mRNA granule formation is dependent on dissociation of polysomes. We conclude that texture analysis is an effective means for quantifying the complex morphological changes induced in neurons by brain ischemia and reperfusion.

Resumo Limpo

textur analysi provid mean quantifi complex chang microscop imag previous show cytoplasm polyadenyl mrnas form mrna granul postischem neuron granul correl protein synthesi inhibit henc cell death util textur analysi softwar mazda quantifi mrna granul photomicrograph pyramid cell layer rat hippocamp region ca around h reperfus min normotherm global cerebr ischemia h reperfus observ variat textur mrna granul amongst sampl readili quantifi textur analysi individu sampl variat consist interpret animaltoanim variat mrna granul reflect timecours mrna granul format also use textur analysi quantifi effect cycloheximid given either brain ischemia mrna granul administ ischemia cycloheximid inhibit mrna granul format administ ischemia prevent mrna granul indic mrna granul format depend dissoci polysom conclud textur analysi effect mean quantifi complex morpholog chang induc neuron brain ischemia reperfus

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