Comput Methods Programs Biomed - A phenomenological mathematical model of the articular cartilage damage.

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Resumo

Articular cartilage (AC) is a biological tissue that allows the distribution of mechanical loads and movement of joints. The presence of these mechanical loads influences the behavior and physiological condition of AC. The loads may cause damaged by fatigue through injuries due to repeated accumulated stresses. The aim of this work is to introduce a phenomenological mathematical model of damage caused by mechanical action. It is considered that tissue failure is a consequence of chondrocyte death and matrix loss, taking into account factors modifying fatigue resistance such as age, body mass index (BMI) and metabolic activity. The model was numerically implemented using the finite elements method and the results obtained allowed us to predict tissue failure at different loading frequencies, different damage sites and variations in damage magnitude. Qualitative concordance between numerical results and experimental data led us to conclude that the model may be useful for physicians and therapists as a prediction tool for prescribing physical exercise and prognosis of joint failure.

Resumo Limpo

articular cartilag ac biolog tissu allow distribut mechan load movement joint presenc mechan load influenc behavior physiolog condit ac load may caus damag fatigu injuri due repeat accumul stress aim work introduc phenomenolog mathemat model damag caus mechan action consid tissu failur consequ chondrocyt death matrix loss take account factor modifi fatigu resist age bodi mass index bmi metabol activ model numer implement use finit element method result obtain allow us predict tissu failur differ load frequenc differ damag site variat damag magnitud qualit concord numer result experiment data led us conclud model may use physician therapist predict tool prescrib physic exercis prognosi joint failur

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