Comput Methods Programs Biomed - ODmixed: a tool to obtain optimal designs for heterogeneous longitudinal studies with dropout.

Tópicos

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{ take(945) account(800) differ(722) }
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Resumo

ODMixed is a computer program to obtain optimal designs for linear mixed models of longitudinal studies. These designs account for heterogeneous correlated errors and for data with dropout. Designs are compared by using relative efficiencies, e.g., between a D-optimal design for homogeneous data and another for heterogeneous data or between a D-optimal design for complete data against another that optimizes designs when data is missing at random. Two examples are worked out to illustrate how researchers could use this computer program to profit of optimal design theory at the planning stage of longitudinal studies.

Resumo Limpo

odmix comput program obtain optim design linear mix model longitudin studi design account heterogen correl error data dropout design compar use relat effici eg doptim design homogen data anoth heterogen data doptim design complet data anoth optim design data miss random two exampl work illustr research use comput program profit optim design theori plan stage longitudin studi

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