Comput Methods Programs Biomed - PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel.

Tópicos

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Resumo

This study presents PKSolver, a freely available menu-driven add-in program for Microsoft Excel written in Visual Basic for Applications (VBA), for solving basic problems in pharmacokinetic (PK) and pharmacodynamic (PD) data analysis. The program provides a range of modules for PK and PD analysis including noncompartmental analysis (NCA), compartmental analysis (CA), and pharmacodynamic modeling. Two special built-in modules, multiple absorption sites (MAS) and enterohepatic circulation (EHC), were developed for fitting the double-peak concentration-time profile based on the classical one-compartment model. In addition, twenty frequently used pharmacokinetic functions were encoded as a macro and can be directly accessed in an Excel spreadsheet. To evaluate the program, a detailed comparison of modeling PK data using PKSolver and professional PK/PD software package WinNonlin and Scientist was performed. The results showed that the parameters estimated with PKSolver were satisfactory. In conclusion, the PKSolver simplified the PK and PD data analysis process and its output could be generated in Microsoft Word in the form of an integrated report. The program provides pharmacokinetic researchers with a fast and easy-to-use tool for routine and basic PK and PD data analysis with a more user-friendly interface.

Resumo Limpo

studi present pksolver freeli avail menudriven addin program microsoft excel written visual basic applic vba solv basic problem pharmacokinet pk pharmacodynam pd data analysi program provid rang modul pk pd analysi includ noncompartment analysi nca compartment analysi ca pharmacodynam model two special builtin modul multipl absorpt site mas enterohepat circul ehc develop fit doublepeak concentrationtim profil base classic onecompart model addit twenti frequent use pharmacokinet function encod macro can direct access excel spreadsheet evalu program detail comparison model pk data use pksolver profession pkpd softwar packag winnonlin scientist perform result show paramet estim pksolver satisfactori conclus pksolver simplifi pk pd data analysi process output generat microsoft word form integr report program provid pharmacokinet research fast easytous tool routin basic pk pd data analysi userfriend interfac

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