Comput. Biol. Med. - Computational studies on strain transmission from a collagen gel construct to a cell and its internal cytoskeletal filaments.

Tópicos

{ model(2220) cell(1177) simul(1124) }
{ estim(2440) model(1874) function(577) }
{ use(2086) technolog(871) perceiv(783) }
{ chang(1828) time(1643) increas(1301) }
{ import(1318) role(1303) understand(862) }
{ blood(1257) pressur(1144) flow(957) }
{ research(1218) medic(880) student(794) }
{ activ(1452) weight(1219) physic(1104) }
{ model(3404) distribut(989) bayesian(671) }
{ data(1737) use(1416) pattern(1282) }
{ featur(3375) classif(2383) classifi(1994) }
{ network(2748) neural(1063) input(814) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ clinic(1479) use(1117) guidelin(835) }
{ method(984) reconstruct(947) comput(926) }
{ research(1085) discuss(1038) issu(1018) }
{ visual(1396) interact(850) tool(830) }
{ sampl(1606) size(1419) use(1276) }
{ activ(1138) subject(705) human(624) }
{ high(1669) rate(1365) level(1280) }
{ use(976) code(926) identifi(902) }
{ result(1111) use(1088) new(759) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ imag(2830) propos(1344) filter(1198) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ care(1570) inform(1187) nurs(1089) }
{ general(901) number(790) one(736) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ system(1050) medic(1026) inform(1018) }
{ model(2341) predict(2261) use(1141) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ studi(1119) effect(1106) posit(819) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ cancer(2502) breast(956) screen(824) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

We developed a mechanical tissue model containing a cell with cytoskeletal filaments inside to investigate how tissue deformation is reflected in the deformation of a cell and its internal cytoskeletal filaments. Tissue that assumes a collagen gel construct was depicted as an isotropic linear elastic material, and the cell was modeled as an assembly of discrete elements including a cell membrane, nuclear envelope, and cytoskeletal filaments. Mechanical behaviors were calculated based on the minimum energy principle. The results demonstrated the effects of the type of tissue deformation on deformations of cytoskeletal filaments. The distribution of strains of cytoskeletal filaments was skewed toward compression when a tissue was stretched, toward stretch when the tissue was compressed, and almost normal when the tissue was sheared. The results also addressed the dependency of deformations of a cell and cytoskeletal filaments on the ratio of the Young's modulus of a tissue to that of a cell. Upon tissue stretching, cell strain increased and the distribution of strains of cytoskeletal filaments broadened on both stretch and compression sides with an increase in the Young's modulus ratio. This suggested that the manner of tissue deformation and the tissue/cell Young's modulus ratio are reflected in the distribution pattern of strains of cytoskeletal filaments. The present model is valuable to understanding the mechanisms of cellular responses in a tissue.

Resumo Limpo

develop mechan tissu model contain cell cytoskelet filament insid investig tissu deform reflect deform cell intern cytoskelet filament tissu assum collagen gel construct depict isotrop linear elast materi cell model assembl discret element includ cell membran nuclear envelop cytoskelet filament mechan behavior calcul base minimum energi principl result demonstr effect type tissu deform deform cytoskelet filament distribut strain cytoskelet filament skew toward compress tissu stretch toward stretch tissu compress almost normal tissu shear result also address depend deform cell cytoskelet filament ratio young modulus tissu cell upon tissu stretch cell strain increas distribut strain cytoskelet filament broaden stretch compress side increas young modulus ratio suggest manner tissu deform tissuecel young modulus ratio reflect distribut pattern strain cytoskelet filament present model valuabl understand mechan cellular respons tissu

Resumos Similares

Comput. Biol. Med. - Biological-data-based finite-element stress analysis of mandibular bone with implant-supported overdenture. ( 0,948645338476614 )
Med Biol Eng Comput - Sensitivity of patient-specific vertebral finite element model from low dose imaging to material properties and loading conditions. ( 0,943256486660506 )
Comput Methods Programs Biomed - Experiment and hydro-mechanical coupling simulation study on the human periodontal ligament. ( 0,939610683765267 )
Med Biol Eng Comput - Sensitivity studies of pediatric material properties on juvenile lumbar spine responses using finite element analysis. ( 0,937521778654585 )
Comput Math Methods Med - Morphological measurement of living cells in methanol with digital holographic microscopy. ( 0,936315357402378 )
Med Biol Eng Comput - Validation efforts and flexibilities of an eight-year-old human juvenile lumbar spine using a three-dimensional finite element model. ( 0,935037299317604 )
Med Biol Eng Comput - Mechanical and microarchitectural analyses of cancellous bone through experiment and computer simulation. ( 0,933314511920802 )
Med Biol Eng Comput - Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model. ( 0,931999921348535 )
J Med Syst - Post-operative assessment of an implant fixation in anterior cruciate ligament reconstructive surgery. ( 0,931940266083999 )
Med Biol Eng Comput - Temporal evolution of skeletal regenerated tissue: what can mechanical investigation add to biological? ( 0,927714769815014 )
Med Biol Eng Comput - Modeling and experimental methods to predict oxygen distribution in bone defects following cell transplantation. ( 0,922511792379351 )
Comput Math Methods Med - A finite element study of micropipette aspiration of single cells: effect of compressibility. ( 0,921176685635879 )
Comput Math Methods Med - Recent advances in computational mechanics of the human knee joint. ( 0,9165169553167 )
Comput Methods Programs Biomed - Subject-specific finite element simulation of the human femur considering inhomogeneous material properties: a straightforward method and convergence study. ( 0,914707568999746 )
Med Biol Eng Comput - Effects of skin wrinkles, age and wetness on mechanical loads in the stratum corneum as related to skin lesions. ( 0,914173876601269 )
Med Biol Eng Comput - Multi-scale study of nanoparticle transport and deposition in tissues during an injection process. ( 0,913973483997385 )
Comput Math Methods Med - A review of the combination of experimental measurements and fibril-reinforced modeling for investigation of articular cartilage and chondrocyte response to loading. ( 0,912072996457482 )
Med Biol Eng Comput - Calibration of the mechanical properties in a finite element model of a lumbar vertebra under dynamic compression up to failure. ( 0,910151058005405 )
Med Biol Eng Comput - Characterization of cellular elastic modulus using structure based double layer model. ( 0,909183944773488 )
Med Biol Eng Comput - Modeling and analysis of coagulated liver tissue and its interaction with a scalpel blade. ( 0,908407426505747 )
Med Biol Eng Comput - A three-dimensional finite element model of the cervical spine: an investigation of whiplash injury. ( 0,908272508169701 )
Int J Comput Assist Radiol Surg - Surgical stent planning: simulation parameter study for models based on DICOM standards. ( 0,906237323250513 )
Med Biol Eng Comput - Biomechanical characterisation of fresh and cadaverous human small intestine: applications for abdominal trauma. ( 0,906174373727801 )
Comput Math Methods Med - Fluid structural analysis of human cerebral aneurysm using their own wall mechanical properties. ( 0,906031900388609 )
Comput Methods Programs Biomed - A phenomenological mathematical model of the articular cartilage damage. ( 0,905848635274368 )
Comput Methods Programs Biomed - Growth plate stress distribution implications during bone development: a simple framework computational approach. ( 0,905170078906752 )
Med Biol Eng Comput - A new method to include the gravitational forces in a finite element model of the scoliotic spine. ( 0,904194511081427 )
Med Biol Eng Comput - The remodeling of alveolar bone supporting the mandibular first molar with different levels of periodontal attachment. ( 0,900713788067537 )
Comput. Biol. Med. - Biomechanical simulation of various surface roughnesses and geometric designs on an immediately loaded dental implant. ( 0,898809628672824 )
Med Biol Eng Comput - Finite element analysis of the influence of loading rate on a model of the full lumbar spine under dynamic loading conditions. ( 0,891899858124619 )
Med Biol Eng Comput - Strain rate-dependent viscohyperelastic constitutive modeling of bovine liver tissue. ( 0,890783597576057 )
Comput. Biol. Med. - Protein transport in the connecting cilium of a photoreceptor cell: modeling the effects of bidirectional protein transitions between the diffusion-driven and motor-driven kinetic states. ( 0,889103001921156 )
Med Biol Eng Comput - A nonlinear finite element simulation of balloon expandable stent for assessment of plaque vulnerability inside a stenotic artery. ( 0,884108658393372 )
Med Biol Eng Comput - 3D finite element analysis on esthetic indirect dental restorations under thermal and mechanical loading. ( 0,880558276431245 )
Med Biol Eng Comput - Continuous flow left ventricular pump support and its effect on regional left ventricular wall stress: finite element analysis study. ( 0,873805807903612 )
Med Biol Eng Comput - Clinically oriented real-time monitoring of the individual's risk for deep tissue injury. ( 0,870407555218914 )
Int J Comput Assist Radiol Surg - Bivariate optimization of orthodontic mini-implant thread height and pitch. ( 0,869356952941324 )
Comput. Biol. Med. - Application of an anatomically-detailed finite element thorax model to investigate pediatric cardiopulmonary resuscitation techniques on hard bed. ( 0,868633017017814 )
Med Biol Eng Comput - Finite element modeling of mitral leaflet tissue using a layered shell approximation. ( 0,86759510835105 )
Med Biol Eng Comput - Effect of heterogeneities in the cellular microstructure on propagation of the cardiac action potential. ( 0,865726653503903 )
Med Biol Eng Comput - Biomechanical analysis of traumatic mesenteric avulsion. ( 0,86522063131294 )
Comput Math Methods Med - Comparative evaluation of osseointegrated dental implants based on platform-switching concept: influence of diameter, length, thread shape, and in-bone positioning depth on stress-based performance. ( 0,864135327030071 )
Comput Methods Programs Biomed - Modelling of mandible bone properties in the numerical analysis of oral implant biomechanics. ( 0,86206140831605 )
Int J Comput Assist Radiol Surg - Real-time simulation of the nonlinear visco-elastic deformations of soft tissues. ( 0,858506812705996 )
Int J Comput Assist Radiol Surg - Multi-scale model for investigating the electrical properties and mechanical properties of liver tissue undergoing ablation. ( 0,85744610953414 )
Comput. Biol. Med. - Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography. ( 0,856846433838992 )
Comput. Biol. Med. - Tooth fracture risk analysis based on a new finite element dental structure models using micro-CT data. ( 0,85634144470616 )
Med Biol Eng Comput - Biomechanics of thoracolumbar junction vertebral fractures from various kinematic conditions. ( 0,853572461604597 )
Med Biol Eng Comput - Biomechanical comparison of fusionless growth modulation corrective techniques in pediatric scoliosis. ( 0,852071094181595 )
Comput Math Methods Med - Superficial collagen fibril modulus and pericellular fixed charge density modulate chondrocyte volumetric behaviour in early osteoarthritis. ( 0,850817625048519 )
Med Biol Eng Comput - Mathematical modeling of stem cell proliferation. ( 0,850496651470503 )
Med Biol Eng Comput - Effects of simulated injury on the anteroinferior glenohumeral capsule. ( 0,847737503864751 )
Int J Comput Assist Radiol Surg - Reality based modeling and simulation of gallbladder shape deformation using variational methods. ( 0,844794390362632 )
Comput Math Methods Med - Modeling the relationship between fluorodeoxyglucose uptake and tumor radioresistance as a function of the tumor microenvironment. ( 0,839870105795201 )
Comput Math Methods Med - Quantitative imaging of young's modulus of soft tissues from ultrasound water jet indentation: a finite element study. ( 0,836361292825256 )
Comput Math Methods Med - Contribution to the determination of in vivo mechanical characteristics of human skin by indentation test. ( 0,835736223266764 )
Comput Methods Programs Biomed - Monte Carlo method for photon heating using temperature-dependent optical properties. ( 0,829300306892791 )
Comput Math Methods Med - The influence of the specimen shape and loading conditions on the parameter identification of a viscoelastic brain model. ( 0,827883430433762 )
Med Biol Eng Comput - Can common adhesion molecules and microtopography affect cellular elasticity? A combined atomic force microscopy and optical study. ( 0,827693200288875 )
Med Biol Eng Comput - In-silico modeling of atrial repolarization in normal and atrial fibrillation remodeled state. ( 0,82381320797242 )
Comput Math Methods Med - A literature review of the numerical analysis of abdominal aortic aneurysms treated with endovascular stent grafts. ( 0,823235195161208 )
Med Biol Eng Comput - Biomechanical modeling of brace treatment of scoliosis: effects of gravitational loads. ( 0,82180792823486 )
Comput Methods Programs Biomed - Anthropometric dependence of the response of a thorax FE model under high speed loading: validation and real world accident replication. ( 0,82114106510084 )
Med Biol Eng Comput - 3D network model of NO transport in tissue. ( 0,818425612827328 )
Med Biol Eng Comput - Influence of heterogeneous and anisotropic tissue conductivity on electric field distribution in deep brain stimulation. ( 0,815884723366417 )
Comput Methods Programs Biomed - Determination of nonlinear fibre-reinforced biphasic poroviscoelastic constitutive parameters of articular cartilage using stress relaxation indentation testing and an optimizing finite element analysis. ( 0,813389104304647 )
Med Biol Eng Comput - Influence of ischemic core muscle fibers on surface depolarization potentials in superfused cardiac tissue preparations: a simulation study. ( 0,812775094561887 )
Comput. Biol. Med. - Design, analysis and verification of a knee joint oncological prosthesis finite element model. ( 0,810873062392116 )
Med Biol Eng Comput - A quasi-brittle continuum damage finite element model of the human proximal femur based on element deletion. ( 0,808145535709369 )
Comput Math Methods Med - Study of tumor growth under hyperthermia condition. ( 0,805475367210126 )
Comput. Biol. Med. - A computational study of the respiratory airflow characteristics in normal and obstructed human airways. ( 0,801010469121304 )
Comput Methods Programs Biomed - A patient specific electro-mechanical model of the heart. ( 0,800926524076474 )
Comput Methods Programs Biomed - Optimal bone density distributions: numerical analysis of the osteocyte spatial influence in bone remodeling. ( 0,799862414495247 )
Comput. Biol. Med. - Modeling porous scaffold microstructure by a reaction-diffusion system and its degradation by hydrolysis. ( 0,795529232867026 )
Comput Methods Programs Biomed - Computational analysis of cartilage implants based on an interpenetrated polymer network for tissue repairing. ( 0,792999878205029 )
Neural Comput - Deficient GABAergic gliotransmission may cause broader sensory tuning in schizophrenia. ( 0,792417413328911 )
Comput. Biol. Med. - Dynamic finite element analysis and moving particle simulation of human enamel on a microscale. ( 0,792136598935343 )
Int J Comput Assist Radiol Surg - Quasi-linear viscoelastic modeling of arterial wall for surgical simulation. ( 0,790899174291215 )
Comput Methods Programs Biomed - Physical modeling with orthotropic material based on harmonic fields. ( 0,790351658615051 )
Comput Biol Chem - Macroscopic simulations of microtubule dynamics predict two steady-state processes governing array morphology. ( 0,788714473577199 )
Med Biol Eng Comput - Backflow length predictions during flow-controlled infusions using a nonlinear biphasic finite element model. ( 0,788291313104189 )
Med Biol Eng Comput - Estimation of the retainer height biomechanical contribution in posterior resin-bonded fixed partial dentures: a structural-thermal coupled finite element analysis. ( 0,787023552147819 )
Comput. Biol. Med. - Prediction of stress shielding around an orthopedic screw: using stress and strain energy density as mechanical stimuli. ( 0,78566041691383 )
Med Biol Eng Comput - Patient-specific finite element modeling of the Cardiokinetix Parachute(?) device: effects on left ventricular wall stress and function. ( 0,785185793602628 )
Med Biol Eng Comput - Finite element analysis of idealised unit cell cancellous structure based on morphological indices of cancellous bone. ( 0,784898963983625 )
Int J Med Robot - A physics-based algorithm for real-time simulation of electrosurgery procedures in minimally invasive surgery. ( 0,780816999162321 )
Comput Math Methods Med - A computational modeling approach for investigating soft tissue balancing in bicruciate retaining knee arthroplasty. ( 0,78005444543835 )
Wiley Interdiscip Rev Syst Biol Med - Ischemic kidney injury and mechanisms of tissue repair. ( 0,777667708433433 )
Med Biol Eng Comput - Biomechanical analysis of the effects of medial meniscectomy on degenerative osteoarthritis. ( 0,776744858411206 )
Comput Math Methods Med - The HYP-RT hypoxic tumour radiotherapy algorithm and accelerated repopulation dose per fraction study. ( 0,772603535388708 )
Neural Comput - Ambient GABA responsible for age-related changes in multistable perception. ( 0,770358852802328 )
J Med Syst - Functional and mechanical evaluation of nerve stretch injury. ( 0,769573714063919 )
Comput. Biol. Med. - Modeling of tumor growth undergoing virotherapy. ( 0,769555519753458 )
Med Biol Eng Comput - Microfabricated substrates as a tool to study cell mechanotransduction. ( 0,769300782396821 )
Comput. Biol. Med. - A computational pipeline for quantification of mouse myocardial stiffness parameters. ( 0,769244934889855 )
Comput Methods Programs Biomed - 3D reconstruction of TMJ after resection of the cyst and the stress-strain analyses. ( 0,767346017689765 )
Comput. Biol. Med. - Modeling skin thermal pain sensation: Role of non-Fourier thermal behavior in transduction process of nociceptor. ( 0,766642153561914 )
Med Biol Eng Comput - Generating anatomical models of the heart and the aorta from medical images for personalized physiological simulations. ( 0,766630411977303 )
Comput Methods Programs Biomed - 2D and 3D finite element analysis of central incisor generated by computerized tomography. ( 0,766443771457307 )
Wiley Interdiscip Rev Syst Biol Med - Integrative approaches for modeling regulation and function of the respiratory system. ( 0,764905335188664 )