Comput. Biol. Med. - An in silico case study of idiopathic dilated cardiomyopathy via a multi-scale model of the cardiovascular system.


{ blood(1257) pressur(1144) flow(957) }
{ model(2220) cell(1177) simul(1124) }
{ bind(1733) structur(1185) ligand(1036) }
{ treatment(1704) effect(941) patient(846) }
{ model(2341) predict(2261) use(1141) }
{ high(1669) rate(1365) level(1280) }
{ signal(2180) analysi(812) frequenc(800) }
{ gene(2352) biolog(1181) express(1162) }
{ activ(1138) subject(705) human(624) }
{ health(1844) social(1437) communiti(874) }
{ use(976) code(926) identifi(902) }
{ system(1976) rule(880) can(841) }
{ error(1145) method(1030) estim(1020) }
{ method(1557) propos(1049) approach(1037) }
{ state(1844) use(1261) util(961) }
{ sampl(1606) size(1419) use(1276) }
{ first(2504) two(1366) second(1323) }
{ result(1111) use(1088) new(759) }
{ process(1125) use(805) approach(778) }
{ take(945) account(800) differ(722) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ control(1307) perform(991) simul(935) }
{ method(984) reconstruct(947) comput(926) }
{ risk(3053) factor(974) diseas(938) }
{ import(1318) role(1303) understand(862) }
{ compound(1573) activ(1297) structur(1058) }
{ spatial(1525) area(1432) region(1030) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ research(1218) medic(880) student(794) }
{ cost(1906) reduc(1198) effect(832) }
{ time(1939) patient(1703) rate(768) }
{ analysi(2126) use(1163) compon(1037) }
{ activ(1452) weight(1219) physic(1104) }
{ method(2212) result(1239) propos(1039) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ care(1570) inform(1187) nurs(1089) }
{ general(901) number(790) one(736) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ visual(1396) interact(850) tool(830) }
{ perform(1367) use(1326) method(1137) }
{ studi(1119) effect(1106) posit(819) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ ehr(2073) health(1662) electron(1139) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ group(2977) signific(1463) compar(1072) }
{ data(3008) multipl(1320) sourc(1022) }
{ intervent(3218) particip(2042) group(1664) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ structur(1116) can(940) graph(676) }
{ cancer(2502) breast(956) screen(824) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ method(1969) cluster(1462) data(1082) }
{ detect(2391) sensit(1101) algorithm(908) }


Mathematical modelling has been used to comprehend the pathology and the assessment of different treatment techniques such as heart failure and left ventricular assist device therapy in the cardiovascular field. In this study, an in-silico model of the heart is developed to understand the effects of idiopathic dilated cardiomyopathy (IDC) as a pathological scenario, with mechanisms described at the cellular, protein and organ levels. This model includes the right and left atria and ventricles, as well as the systemic and pulmonary arteries and veins. First, a multi-scale model of the whole heart is simulated for healthy conditions. Subsequently, the model is modified at its microscopic and macroscopic spatial scale to obtain the characteristics of IDC. The extracellular calcium concentration, the binding affinity of calcium binding proteins and the maximum and minimum elastances have been identified as key parameters across all relevant scales. The modified parameters cause a change in (a) intracellular calcium concentration characterising cellular properties, such as calcium channel currents or the action potential, (b) the proteins being involved in the sliding filament mechanism and the proportion of the attached crossbridges at the protein level, as well as (c) the pressure and volume values at the organ level. This model allows to obtain insight and understanding of the effects of the treatment techniques, from a physiological and biological point of view.

Resumo Limpo

mathemat model use comprehend patholog assess differ treatment techniqu heart failur left ventricular assist devic therapi cardiovascular field studi insilico model heart develop understand effect idiopath dilat cardiomyopathi idc patholog scenario mechan describ cellular protein organ level model includ right left atria ventricl well system pulmonari arteri vein first multiscal model whole heart simul healthi condit subsequ model modifi microscop macroscop spatial scale obtain characterist idc extracellular calcium concentr bind affin calcium bind protein maximum minimum elast identifi key paramet across relev scale modifi paramet caus chang intracellular calcium concentr characteris cellular properti calcium channel current action potenti b protein involv slide filament mechan proport attach crossbridg protein level well c pressur volum valu organ level model allow obtain insight understand effect treatment techniqu physiolog biolog point view

Resumos Similares

Comput Methods Programs Biomed - A model of ventilation of the healthy human lung. ( 0,788517647930459 )
Comput Math Methods Med - Mathematical modeling of radiofrequency ablation for varicose veins. ( 0,780193805037239 )
Med Biol Eng Comput - Computational analysis of nanoparticle adhesion to endothelium: effects of kinetic rate constants and wall shear rates. ( 0,766816675859707 )
Comput. Biol. Med. - Simulation of a pulsatile non-Newtonian flow past a stenosed 2D artery with atherosclerosis. ( 0,761726746678716 )
Comput Methods Programs Biomed - In silico study of the haemodynamic effects induced by mechanical ventilation and biventricular pacemaker. ( 0,758010244451774 )
J Clin Monit Comput - Impact of central hypovolemia on photoplethysmographic waveform parameters in healthy volunteers part 2: frequency domain analysis. ( 0,750492766223689 )
Med Biol Eng Comput - Mechanical behaviour and rupture of normal and pathological human ascending aortic wall. ( 0,74864560093461 )
Comput Math Methods Med - Evaluation of a model-based hemodynamic monitoring method in a porcine study of septic shock. ( 0,742380594804465 )
Comput Methods Programs Biomed - Computer simulation of MHD blood conveying gold nanoparticles as a third grade non-Newtonian nanofluid in a hollow porous vessel. ( 0,739302322842375 )
Comput. Biol. Med. - Effect of CPAP therapy on daytime cardiovascular regulations in patients with obstructive sleep apnea. ( 0,738105845849456 )
Comput. Biol. Med. - The hemodynamic alterations induced by the vascular angular deformation in stent-assisted coiling of bifurcation aneurysms. ( 0,737987589902356 )
Comput Math Methods Med - Evaluating the hemodynamical response of a cardiovascular system under support of a continuous flow left ventricular assist device via numerical modeling and simulations. ( 0,732185261527492 )
J Clin Monit Comput - Changes in R-Wave amplitude in DII lead is less sensitive than pulse pressure variation to detect changes in stroke volume after fluid challenge in ICU patients postoperatively to cardiac surgery. ( 0,730423068474708 )
Med Biol Eng Comput - Fully coupled fluid-structure interaction model of congenital bicuspid aortic valves: effect of asymmetry on hemodynamics. ( 0,729456165082855 )
Med Biol Eng Comput - The consequences of the mechanical environment of peripheral arteries for nitinol stenting. ( 0,72929279632296 )
Comput. Biol. Med. - Computational analysis of the importance of flow synchrony for cardiac ventricular assist devices. ( 0,726928038553975 )
Med Biol Eng Comput - Characterization of skin dermis microcirculation in flow-mediated dilation using optical sensor with pressurization mechanism. ( 0,726218487579006 )
IEEE J Biomed Health Inform - Experimental investigation of the influence of the aortic stiffness on hemodynamics in the ascending aorta. ( 0,725216563465596 )
J Clin Monit Comput - Radial-femoral concordance in time and frequency domain-based estimates of systemic arterial respiratory variation. ( 0,722902719133234 )
Med Biol Eng Comput - Cardiac oxygen supply is compromised during the night in hypertensive patients. ( 0,72036179126099 )
Comput. Biol. Med. - Biomechanical behaviors of curved artery with flexible wall: a numerical study using fluid-structure interaction method. ( 0,720347569014419 )
Comput Math Methods Med - Simulation of arrhythmogenic effect of rogue RyRs in failing heart by using a coupled model. ( 0,719349450280157 )
Comput Math Methods Med - Computational fluid dynamics simulations of contrast agent bolus dispersion in a coronary bifurcation: impact on MRI-based quantification of myocardial perfusion. ( 0,718636593588665 )
Med Biol Eng Comput - Aortic pressure wave reconstruction during exercise is improved by adaptive filtering: a pilot study. ( 0,716796476709166 )
Comput. Biol. Med. - Simulating ventilation distribution in heterogenous lung injury using a binary tree data structure. ( 0,715684015979478 )
J Clin Monit Comput - Impact of central hypovolemia on photoplethysmographic waveform parameters in healthy volunteers. Part 1: time domain analysis. ( 0,715069942431437 )
J Clin Monit Comput - Variations in the pre-ejection period induced by ventricular extra systoles may be feasible to predict fluid responsiveness. ( 0,713990397530342 )
Med Biol Eng Comput - Timing and size of flow impingement in a giant intracranial aneurysm at the internal carotid artery. ( 0,713809933744273 )
Comput Math Methods Med - Numerical study for blood flow in pulmonary arteries after repair of tetralogy of Fallot. ( 0,711677175679715 )
Comput Methods Programs Biomed - Mechanical ventilation and thoracic artificial lung assistance during mechanical circulatory support with PUCA pump: in silico study. ( 0,711372972368961 )
Comput Math Methods Med - Simulation of the Frank-Starling Law of the Heart. ( 0,710800579596441 )
J Clin Monit Comput - Combination of continuous pulse pressure variation monitoring and cardiac filling pressure to predict fluid responsiveness. ( 0,71066239414302 )
J Clin Monit Comput - Pulmonary artery pulsatility is the main cause of cardiogenic oscillations. ( 0,71051945596446 )
J Clin Monit Comput - Comparison of cardiac output determined by bioimpedance and bioreactance methods at rest and during exercise. ( 0,71014122453339 )
Comput Math Methods Med - Relationship between concentration difference of different density lipoproteins and shear stress in atherosclerosis. ( 0,709726424781665 )
Comput Math Methods Med - Impact of competitive flow on hemodynamics in coronary surgery: numerical study of ITA-LAD model. ( 0,709691096727174 )
J Clin Monit Comput - Respiratory and non-respiratory sinus arrhythmia: implications for heart rate variability. ( 0,708022919572019 )
Med Biol Eng Comput - The effect of aortic wall and aortic leaflet stiffening on coronary hemodynamic: a fluid-structure interaction study. ( 0,706898531762229 )
J Med Syst - Telemetry design of a vital sign recording system. ( 0,706541260741938 )
Comput Methods Programs Biomed - A model of perfusion of the healthy human lung. ( 0,705673167987282 )
Comput Math Methods Med - Simulation of exercise-induced syncope in a heart model with severe aortic valve stenosis. ( 0,704892259547815 )
Med Biol Eng Comput - Biomechanical analysis of the splenic avulsion mechanism. ( 0,703036194304015 )
Comput Math Methods Med - Plasma volume expansion resulting from intravenous glucose tolerance test. ( 0,70117837531587 )
Comput Math Methods Med - Influence of distal resistance and proximal stiffness on hemodynamics and RV afterload in progression and treatments of pulmonary hypertension: a computational study with validation using animal models. ( 0,698670596231223 )
Comput Math Methods Med - Mathematical analysis of non-Newtonian blood flow in stenosis narrow arteries. ( 0,698223831946133 )
Med Biol Eng Comput - Electropermeabilization of endocytotic vesicles in B16 F1 mouse melanoma cells. ( 0,697775899313558 )
Med Biol Eng Comput - Model-based correction of the influence of body position on continuous segmental and hand-to-foot bioimpedance measurements. ( 0,695431266406011 )
Comput Math Methods Med - Finite element modelling of pulsatile blood flow in idealized model of human aortic arch: study of hypotension and hypertension. ( 0,694910851504337 )
Med Biol Eng Comput - Investigation of photoplethysmographic signals and blood oxygen saturation values on healthy volunteers during cuff-induced hypoperfusion using a multimode PPG/SpO2 sensor. ( 0,693964890612047 )
Med Biol Eng Comput - A coupled flow-acoustic computational study of bruits from a modeled stenosed artery. ( 0,692712576117596 )
Med Biol Eng Comput - Evaluation of the hemodynamics in straight 6-mm and tapered 6- to 8-mm grafts as upper arm hemodialysis vascular access. ( 0,692538036831538 )
Comput Math Methods Med - Pressure dynamic characteristics of pressure controlled ventilation system of a lung simulator. ( 0,692163369130204 )
J Clin Monit Comput - Continuous minimally invasive peri-operative monitoring of cardiac output by pulmonary capnotracking: comparison with thermodilution and transesophageal echocardiography. ( 0,69193587052847 )
J Clin Monit Comput - Impact of skin incision on the pleth variability index. ( 0,691931670703456 )
Comput. Biol. Med. - Computational study of thermal effects of large blood vessels in human knee joint. ( 0,691447019827042 )
J Clin Monit Comput - Heart sounds analysis via esophageal stethoscope system in beagles. ( 0,691062443767661 )
Comput Math Methods Med - Effect of the polydispersity of RBCs on the recovery rate of RBCs during the removal of CPAs. ( 0,690302958550546 )
Med Biol Eng Comput - Arterial reservoir-excess pressure and ventricular work. ( 0,689394276920394 )
J Clin Monit Comput - Transthoracic electrical bioimpedence cardiac output: comparison with multigated equillibrium radionuclide cardiography. ( 0,688252050727097 )
J Clin Monit Comput - Hemodynamic volumetry using transpulmonary ultrasound dilution (TPUD) technology in a neonatal animal model. ( 0,687484299723051 )
J Clin Monit Comput - In-line pressure within a HOTLINE? Fluid Warmer, under various flow conditions. ( 0,687287983256491 )
Med Biol Eng Comput - Assessment of dynamic cerebral autoregulation and cerebral carbon dioxide reactivity during normothermic cardiopulmonary bypass. ( 0,687043988906026 )
J Clin Monit Comput - The relationship between the area of peripherally-derived pressure volume loops and systemic vascular resistance. ( 0,684496439943721 )
Med Biol Eng Comput - Comparison of four mathematical models to analyze indicator-dilution curves in the coronary circulation. ( 0,682872463996172 )
J Clin Monit Comput - Assessment of the effect of rapid crystalloid infusion on stroke volume variation and pleth variability index after a preoperative fast. ( 0,682194996872474 )
J Clin Monit Comput - Capability of a new paediatric oesophageal Doppler monitor to detect changes in cardiac output during testing of external pacemakers after cardiac surgery. ( 0,68206510802771 )
J Med Syst - Human cardiovascular model and applications. ( 0,681271750170153 )
Comput Math Methods Med - Linear and nonlinear heart rate variability indexes in clinical practice. ( 0,680771835784693 )
Comput. Biol. Med. - Investigating the relationships between peristaltic contraction and fluid transport in the human colon using Smoothed Particle Hydrodynamics. ( 0,679894246897306 )
J Clin Monit Comput - Heart rate turbulence for guiding electric therapy in patients with cardiac failure. ( 0,677421241877502 )
Comput Methods Programs Biomed - Impact of pulmonary vascular stiffness and vasodilator treatment in pediatric pulmonary hypertension: 21 patient-specific fluid-structure interaction studies. ( 0,676834167691858 )
J Clin Monit Comput - Assessment of cerebral oxygenation using near infrared spectroscopy during isovolemic hemodilution in pediatric patients. ( 0,6766790524084 )
Wiley Interdiscip Rev Syst Biol Med - Integration of cardiovascular regulation by the blood/endothelium cell-free layer. ( 0,676318645671074 )
J Clin Monit Comput - Decrease in pulmonary artery pressure after administration of thoracic epidural anesthesia in a patient with Marfan syndrome awaiting aortic valve replacement procedure. ( 0,675986267268694 )
Comput. Biol. Med. - Numerical investigation of blood flow in three-dimensional porcine left anterior descending artery with various stenoses. ( 0,675587246863691 )
Comput Math Methods Med - A new high-resolution spectral approach to noninvasively evaluate wall deformations in arteries. ( 0,672159367478339 )
Comput. Biol. Med. - A general model for continuous noninvasive pulmonary artery pressure estimation. ( 0,670827977983617 )
Med Biol Eng Comput - Enhanced phase synchronization of blood flow oscillations between heated and adjacent non-heated sacral skin. ( 0,670663194029237 )
J Clin Monit Comput - Transesophageal echocardiography and intraoperative phlebotomy during surgical repair of coarctation of aorta in a patient with atrial septal defect, moderately severe mitral regurgitation and severe pulmonary hypertension. ( 0,670265157589427 )
Med Biol Eng Comput - Toward hemodynamic diagnosis of carotid artery stenosis based on ultrasound image data and computational modeling. ( 0,6678537806046 )
Comput Methods Programs Biomed - Numerical analysis of coronary artery bypass grafts: an over view. ( 0,667589169288209 )
Comput Math Methods Med - Computational fluid dynamics analysis of the effect of plaques in the left coronary artery. ( 0,666669962974225 )
Comput. Biol. Med. - Glucose predictability, blood capillary permeability, and glucose utilization rate in subcutaneous, skeletal muscle, and visceral fat tissues. ( 0,665596653986246 )
J Clin Monit Comput - Evaluation of mean systemic filling pressure from pulse contour cardiac output and central venous pressure. ( 0,665074810122558 )
Comput. Biol. Med. - Mechanistic electronic model to simulate and predict the effect of heat stress on the functional genomics of HO-1 system: Vasodilation. ( 0,664640588784755 )
J Clin Monit Comput - Variations in the pre-ejection period induced by deep breathing do not predict the hemodynamic response to early haemorrhage in healthy volunteers. ( 0,663875956940567 )
Med Biol Eng Comput - The influence of intraluminal thrombus on noninvasive abdominal aortic aneurysm wall distensibility measurement. ( 0,662953338236275 )
Comput. Biol. Med. - Blood glucose level reconstruction as a function of transcapillary glucose transport. ( 0,662715696225055 )
Med Biol Eng Comput - Subject-specific estimation of central aortic blood pressure via system identification: preliminary in-human experimental study. ( 0,661648933537502 )
J Clin Monit Comput - Noninvasive continuous hemodynamic monitoring. ( 0,660520088395492 )
Med Biol Eng Comput - Monitoring intracellular, interstitial, and intravascular volume changes during fluid management procedures. ( 0,659223366468454 )
J Med Syst - Mathematical models of real geometrical factors in restricted blood vessels for the analysis of CAD (coronary artery diseases) using Legendre, Boubaker and Bessel polynomials. ( 0,659130944983867 )
Comput Methods Programs Biomed - Quantitative analysis of digital subtraction angiography using optical flow method on occlusive cerebrovascular disease. ( 0,658936841768831 )
Comput Math Methods Med - Therapeutic vascular compliance change may cause significant variation in coronary perfusion: a numerical study. ( 0,657195137246596 )
Comput Methods Programs Biomed - Computational analysis of cartilage implants based on an interpenetrated polymer network for tissue repairing. ( 0,656915261162002 )
BMC Med Inform Decis Mak - Clinical decision support of therapeutic drug monitoring of phenytoin: measured versus adjusted phenytoin plasma concentrations. ( 0,656572059735518 )
J Clin Monit Comput - Fluid responsiveness is about stroke volume, and not pulse pressure Yogi: the power of Doppler fluid management and cardiovascular monitoring. ( 0,655342246455738 )
Med Biol Eng Comput - Computational model for estimating the short- and long-term cardiac response to arteriovenous fistula creation for hemodialysis. ( 0,65529422276256 )
J Clin Monit Comput - Arterial pressure waveform derived cardiac output FloTrac/Vigileo system (third generation software): comparison of two monitoring sites with the thermodilution cardiac output. ( 0,655203187673638 )
Comput Math Methods Med - CFD modelling of abdominal aortic aneurysm on hemodynamic loads using a realistic geometry with CT. ( 0,654684734254012 )