Comput. Biol. Med. - Averaging of diffusion tensor imaging direction-encoded color maps for localizing substantia nigra.

Tópicos

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Resumo

Diffusion tensor imaging (DTI) is a form of MRI that has been used extensively to map in vivo the white matter architecture of the human brain. It is also used for mapping subcortical nuclei because of its general sensitivity to tissue orientation differences and effects of iron accumulation on the diffusion signal. While DTI provides excellent spatial resolution in individual subjects, a challenge is visualizing consistent patterns of diffusion orientation across subjects. Here we present a simple method for averaging direction-encoded color anisotropy maps in standard space, explore this technique for visualizing the substantia nigra (SN) in relation to other midbrain structures, and show with signal-to-noise analysis that averaging improves the direction-encoded color signature. SN is distinguished on averaged maps from neighboring structures, including red nucleus (RN) and cerebral crus, and is proximal to SN location from existing brain atlases and volume of interest (VOI) delineation on individual scans using two blinded raters.

Resumo Limpo

diffus tensor imag dti form mri use extens map vivo white matter architectur human brain also use map subcort nuclei general sensit tissu orient differ effect iron accumul diffus signal dti provid excel spatial resolut individu subject challeng visual consist pattern diffus orient across subject present simpl method averag directionencod color anisotropi map standard space explor techniqu visual substantia nigra sn relat midbrain structur show signaltonois analysi averag improv directionencod color signatur sn distinguish averag map neighbor structur includ red nucleus rn cerebr crus proxim sn locat exist brain atlas volum interest voi delin individu scan use two blind rater

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