Comput. Biol. Med. - Computational analysis of the importance of flow synchrony for cardiac ventricular assist devices.

Tópicos

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Resumo

This paper presents a patient customised fluid-solid mechanics model of the left ventricle (LV) supported by a left ventricular assist device (LVAD). Six simulations were conducted across a range of LVAD flow protocols (constant flow, sinusoidal in-sync and sinusoidal counter-sync with respect to the cardiac cycle) at two different LVAD flow rates selected so that the aortic valve would either open (60mLs(-1)) or remain shut (80mLs(-1)). The simulation results indicate that varying LVAD flow in-sync with the cardiac cycle improves both myocardial unloading and the residence times of blood in the left ventricle. In the simulations, increasing LVAD flow during myocardial contraction and decreasing it during diastole improved the mixing of blood in the LV cavity. Additionally, this flow protocol had the effect of partly homogenising work across the myocardium when the aortic valve did not open, reducing myocardial stress and thereby improving unloading.

Resumo Limpo

paper present patient customis fluidsolid mechan model left ventricl lv support left ventricular assist devic lvad six simul conduct across rang lvad flow protocol constant flow sinusoid insync sinusoid countersync respect cardiac cycl two differ lvad flow rate select aortic valv either open mls remain shut mls simul result indic vari lvad flow insync cardiac cycl improv myocardi unload resid time blood left ventricl simul increas lvad flow myocardi contract decreas diastol improv mix blood lv caviti addit flow protocol effect part homogenis work across myocardium aortic valv open reduc myocardi stress therebi improv unload

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