Comput. Biol. Med. - Inter- and intra-observer variability analysis of completely automated cIMT measurement software (AtheroEdge?) and its benchmarking against commercial ultrasound scanner and expert Readers.


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The purpose of this study was to evaluate the measurement error and inter- and intra-observer variability of completely off-line automated and semi-automated carotid intima-media thickness (cIMT) measurement software (AtheroEdge?). Two hundred carotid ultrasound images from 50 asymptomatic women were analyzed. AtheroEdge? was benchmarked against a commercial system (Syngo, Siemens) using automated and semi-automated modes. The measurement error and inter- and intra-observer variability of AtheroEdge? were tested using three readings. The measurement error of AtheroEdge? compared to the commercial software was 0.002?0.019mm (r=0.99) in the automated mode and -0.001?0.004mm in the semi-automated mode (r=0.99). The measurement error of AtheroEdge? compared to the mean value of the three expert Readers (cIMT bias) for the automated and semi-automated methods was -0.0004?0.158mm and -0.008?0.157mm, respectively. The Figure-of-Merit was 99.8% and 99.9% when compared to the commercial ultrasound scanner (using the automated and semi-automated method, respectively) and was 99.9% and 98.9% when compared to the mean value of the three expert Readers. Regarding inter- and intra-observer variability, the intra-class correlation coefficient of the three independent users using the semi-automated AtheroEdge? was 0.98. AtheroEdge? showed a measurement performance comparable to the commercial ultrasound scanner software and the expert Readers' tracings. AtheroEdge? belongs to a class of automated systems that could find application in processing large datasets for common carotid arteries, avoiding subjectivity in cIMT measurements.

Resumo Limpo

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