Comput. Biol. Med. - Numerical investigation into blood clotting at the bone-dental implant interface in the presence of an electrical stimulus.

Tópicos

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Resumo

The insertion of a dental implant activates a sequence of wound healing events ending with bone formation and implant osseointegration. This sequence starts with the blood coagulation process and the formation of a fibrin network that detains spilt blood. Fibrin formation can be simplified as the kinetic reaction between thrombin and fibrinogen preceding the conversion of fibrinogen into fibrin. Based on experimental observations of the electrical properties of these molecules, we present a hypothesis for the mechanism of a static electrical stimulus in controlling the formation of the blood clot. Specifically, the electrical stimulus increases the fibrin network formation in such a way that a preferential region of higher fibrin density is obtained. This hypothesis is validated by means of a numerical model for the blood clot formation at the bone-dental implant interface. Numerical results compare favorably to experimental observations for blood clotting with and without the static electrical stimulus. It is concluded that the density of the fibrin network depends on the strength of the static electrical stimulus, and that the blood clot formation has a preferential direction of formation in the presence of the electrical signal.

Resumo Limpo

insert dental implant activ sequenc wound heal event end bone format implant osseointegr sequenc start blood coagul process format fibrin network detain spilt blood fibrin format can simplifi kinet reaction thrombin fibrinogen preced convers fibrinogen fibrin base experiment observ electr properti molecul present hypothesi mechan static electr stimulus control format blood clot specif electr stimulus increas fibrin network format way preferenti region higher fibrin densiti obtain hypothesi valid mean numer model blood clot format bonedent implant interfac numer result compar favor experiment observ blood clot without static electr stimulus conclud densiti fibrin network depend strength static electr stimulus blood clot format preferenti direct format presenc electr signal

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