Comput. Biol. Med. - Interplay between Fur and HNS in controlling virulence gene expression in Salmonella typhimurium.

Tópicos

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Resumo

Salmonella enterica is responsible for a large number of diseases in a wide-range of hosts. Two of the global regulators involved in controlling gene expression during the infection cycle of the bacterium are Fur and HNS. In this paper, we demonstrate computationally that Fur and HNS have disproportionately high density of binding sites in the Pathogenicity Islands on the Salmonella chromosome. Moreover, the frequency of binding sites for the two proteins is correlated throughout the genome of the organism. These results indicate a complex interplay between Fur and HNS in regulating cellular global behavior.

Resumo Limpo

salmonella enterica respons larg number diseas widerang host two global regul involv control gene express infect cycl bacterium fur hns paper demonstr comput fur hns disproportion high densiti bind site pathogen island salmonella chromosom moreov frequenc bind site two protein correl throughout genom organ result indic complex interplay fur hns regul cellular global behavior

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