Comput. Biol. Med. - Unbiased entropy estimates in stress: a parameter study.

Tópicos

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Resumo

This study proposes a method for obtaining a stable working point that enables the unbiased estimates of the approximate entropy and the sample entropy. Pattern length, normalized threshold, time delay and tines series length are levels of freedom that are considered. Pulse interval signals used for the experiment are recorded from laboratory animals with different likelihood of developing cardiovascular disease--normal and borderline hypertensive rats--exposed to the acute and to the chronic stress. It is shown that the threshold level is the major source of the instability, and that the generally accepted and widely used methods for a threshold choice may lead to an incorrect psychological interpretation. A method for the threshold level correction is proposed.

Resumo Limpo

studi propos method obtain stabl work point enabl unbias estim approxim entropi sampl entropi pattern length normal threshold time delay tine seri length level freedom consid puls interv signal use experi record laboratori anim differ likelihood develop cardiovascular diseasenorm borderlin hypertens ratsexpos acut chronic stress shown threshold level major sourc instabl general accept wide use method threshold choic may lead incorrect psycholog interpret method threshold level correct propos

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