Comput. Biol. Med. - Glucose predictability, blood capillary permeability, and glucose utilization rate in subcutaneous, skeletal muscle, and visceral fat tissues.

Tópicos

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Resumo

This study suggests an approach for the comparison and evaluation of particular compartments with modest experimental setup costs. A glucose level prediction model was used to evaluate the compartment's glucose transport rate across the blood capillary membrane and the glucose utilization rate by the cells. The glucose levels of the blood, subcutaneous tissue, skeletal muscle tissue, and visceral fat were obtained in experiments conducted on hereditary hypertriglyceridemic rats. After the blood glucose level had undergone a rapid change, the experimenter attempted to reach a steady blood glucose level by manually correcting the glucose infusion rate and maintaining a constant insulin infusion rate. The interstitial fluid glucose levels of subcutaneous tissue, skeletal muscle tissue, and visceral fat were evaluated to determine the reaction delay compared with the change in the blood glucose level, the interstitial fluid glucose level predictability, the blood capillary permeability, the effect of the concentration gradient, and the glucose utilization rate. Based on these data, the glucose transport rate across the capillary membrane and the utilization rate in a particular tissue were determined. The rates obtained were successfully verified against positron emission tomography experiments. The subcutaneous tissue exhibits the lowest and the most predictable glucose utilization rate, whereas the skeletal muscle tissue has the greatest glucose utilization rate. In contrast, the visceral fat is the least predictable and has the shortest reaction delay compared with the change in the blood glucose level. The reaction delays obtained for the subcutaneous tissue and skeletal muscle tissue were found to be approximately equal using a metric based on the time required to reach half of the increase in the interstitial fluid glucose level.

Resumo Limpo

studi suggest approach comparison evalu particular compart modest experiment setup cost glucos level predict model use evalu compart glucos transport rate across blood capillari membran glucos util rate cell glucos level blood subcutan tissu skelet muscl tissu viscer fat obtain experi conduct hereditari hypertriglyceridem rat blood glucos level undergon rapid chang experiment attempt reach steadi blood glucos level manual correct glucos infus rate maintain constant insulin infus rate interstiti fluid glucos level subcutan tissu skelet muscl tissu viscer fat evalu determin reaction delay compar chang blood glucos level interstiti fluid glucos level predict blood capillari permeabl effect concentr gradient glucos util rate base data glucos transport rate across capillari membran util rate particular tissu determin rate obtain success verifi positron emiss tomographi experi subcutan tissu exhibit lowest predict glucos util rate wherea skelet muscl tissu greatest glucos util rate contrast viscer fat least predict shortest reaction delay compar chang blood glucos level reaction delay obtain subcutan tissu skelet muscl tissu found approxim equal use metric base time requir reach half increas interstiti fluid glucos level

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