Comput. Biol. Med. - Simulation of a pulsatile non-Newtonian flow past a stenosed 2D artery with atherosclerosis.

Tópicos

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Resumo

Atherosclerotic plaque can cause severe stenosis in the artery lumen. Blood flow through a substantially narrowed artery may have different flow characteristics and produce different forces acting on the plaque surface and artery wall. The disturbed flow and force fields in the lumen may have serious implications on vascular endothelial cells, smooth muscle cells, and circulating blood cells. In this work a simplified model is used to simulate a pulsatile non-Newtonian blood flow past a stenosed artery caused by atherosclerotic plaques of different severity. The focus is on a systematic parameter study of the effects of plaque size/geometry, flow Reynolds number, shear-rate dependent viscosity and flow pulsatility on the fluid wall shear stress and its gradient, fluid wall normal stress, and flow shear rate. The computational results obtained from this idealized model may shed light on the flow and force characteristics of more realistic blood flow through an atherosclerotic vessel.

Resumo Limpo

atherosclerot plaqu can caus sever stenosi arteri lumen blood flow substanti narrow arteri may differ flow characterist produc differ forc act plaqu surfac arteri wall disturb flow forc field lumen may serious implic vascular endotheli cell smooth muscl cell circul blood cell work simplifi model use simul pulsatil nonnewtonian blood flow past stenos arteri caus atherosclerot plaqu differ sever focus systemat paramet studi effect plaqu sizegeometri flow reynold number shearrat depend viscos flow pulsatil fluid wall shear stress gradient fluid wall normal stress flow shear rate comput result obtain ideal model may shed light flow forc characterist realist blood flow atherosclerot vessel

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