Comput. Biol. Med. - Estimation of saline-mixed tissue conductivity and ablation lesion size.

Tópicos

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Resumo

In radiofrequency ablation (RFA), saline infusion is beneficial for enhancing electrical conductivity, which allows more energy dissipation into target tissue, resulting in increased lesion size. Computational simulation has been a popular method to estimate lesion size from RFA treatment, but it has not been used effectively for saline-infused RFA, for lack of methods to address the conductivity properties of saline-tissue mixtures. To fill this gap, we propose a microscopic mixture model to derive the effective temperature-dependent conductivities of a saline-tissue mixture. We modeled a small block of 6% hypertonic saline-infused liver tissue as a 1 ? 1 ? 1 cm cube, which was divided into 64-1000 elements, with each element representing either liver tissue or saline. A 1:1 mixing of saline and liver tissue was assumed to calculate the effective conductivities at 30, 50, 70, and 90?C. Different mixing conditions (2:1 and 1:2 of saline to liver tissue) were also tested to observe the effect of mixing ratio on the resulting data. Then, the derived conductivities were applied for 3D hypertonic saline-infused RFA simulation. The results matched our previous experimental measurements within 13%. The proposed model is customizable in constructing mixtures of multiple components, and can thus be expanded to include the effects of various anatomical microstructures and materials.

Resumo Limpo

radiofrequ ablat rfa salin infus benefici enhanc electr conduct allow energi dissip target tissu result increas lesion size comput simul popular method estim lesion size rfa treatment use effect salineinfus rfa lack method address conduct properti salinetissu mixtur fill gap propos microscop mixtur model deriv effect temperaturedepend conduct salinetissu mixtur model small block hyperton salineinfus liver tissu cm cube divid element element repres either liver tissu salin mix salin liver tissu assum calcul effect conduct c differ mix condit salin liver tissu also test observ effect mix ratio result data deriv conduct appli d hyperton salineinfus rfa simul result match previous experiment measur within propos model customiz construct mixtur multipl compon can thus expand includ effect various anatom microstructur materi

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