Comput. Biol. Med. - Protein transport in the connecting cilium of a photoreceptor cell: modeling the effects of bidirectional protein transitions between the diffusion-driven and motor-driven kinetic states.

Tópicos

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Resumo

Physics of protein transport through the connecting cilium (CC) of a photoreceptor cell is a long-standing question in cellular biology. There is evidence implicating both molecular motor-driven and diffusion-driven modes of intracellular transport. Based on available experimental clues, this paper develops a new model for intraflagellar transport (IFT) of proteins synthesized in the inner segment and transported through the CC to the outer segment of a photoreceptor cell. The model accounts for the competition between two modes of protein transport: molecular motor-driven transport and diffusion. The obtained solutions made it possible to calculate how the number of protein molecules transported through the CC at a given time depends on their diffusivity. Modeling results were compared with published experimental estimates, and conclusions about possible contributions of diffusion to IFT were made.

Resumo Limpo

physic protein transport connect cilium cc photoreceptor cell longstand question cellular biolog evid implic molecular motordriven diffusiondriven mode intracellular transport base avail experiment clue paper develop new model intraflagellar transport ift protein synthes inner segment transport cc outer segment photoreceptor cell model account competit two mode protein transport molecular motordriven transport diffus obtain solut made possibl calcul number protein molecul transport cc given time depend diffus model result compar publish experiment estim conclus possibl contribut diffus ift made

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