Comput. Biol. Med. - On a reusable and multilevel methodology for modeling and simulation of pharmacokinetic-physiological systems: a preliminary study.

Tópicos

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{ model(2656) set(1616) predict(1553) }
{ featur(3375) classif(2383) classifi(1994) }
{ framework(1458) process(801) describ(734) }
{ model(2220) cell(1177) simul(1124) }
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{ research(1085) discuss(1038) issu(1018) }
{ medic(1828) order(1363) alert(1069) }
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{ patient(2837) hospit(1953) medic(668) }
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{ age(1611) year(1155) adult(843) }
{ signal(2180) analysi(812) frequenc(800) }
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{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
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Resumo

The intrinsic characteristics of physiological systems demand two critical requirements at the time of mathematical modeling: multilevel description and reusability. These features are not properly satisfied by current methodologies. In this paper the design of a multilevel and reusable methodology for modeling pharmacokinetic-physiological systems is presented. It has been implemented under a compliant modeling language to validate its reliability, obtaining a simulation components library, LibPK. A 3-pool urea kinetic model, whose vascular pool includes red blood cells, was built by means of LibPK. This model successfully confirmed the ability of this technology and the underlying methodology for addressing multilevel and reusability features, surpassing other physiologically based pharmacokinetic modeling technologies.

Resumo Limpo

intrins characterist physiolog system demand two critic requir time mathemat model multilevel descript reusabl featur proper satisfi current methodolog paper design multilevel reusabl methodolog model pharmacokineticphysiolog system present implement compliant model languag valid reliabl obtain simul compon librari libpk pool urea kinet model whose vascular pool includ red blood cell built mean libpk model success confirm abil technolog under methodolog address multilevel reusabl featur surpass physiolog base pharmacokinet model technolog

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