Comput. Biol. Med. - Numerical models of net-structure stents inserted into arteries.

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Resumo

TRODUCTION: Restenosis is strongly attributed to stresses caused by stent-artery interactions generated in the artery after balloon angioplasty. Numerical methods are often used to examine the stent-artery mechanical interactions. To overcome the extensive computational requirements demanded by these simulations, simplifications are needed.OBJECTIVE: We introduce simplified models to calculate the mechanical interactions between net-structured stents and arteries, and discuss their validity and implications.METHODS: 2D simplified numerical models are suggested, which allow cost effective assessment of arterial stresses and the potential damage factor (DF). In these models, several contact problems were solved for arteries with hyper elastic mechanical properties. Stresses were calculated for a large range of cases and for different numerical model types. The effects of model simplifications, oversizing mismatch and stenosis rate and length and symmetry on the resulting stresses were analyzed.RESULTS & CONCLUSIONS: Results obtained from planar 2D models were found in good agreement with results obtained from complex 3D models for cases with axisymmetric constant or varying stenosis. This high correlation between the results of 3D cases with varying stenosis and the more simple 2D cases can be used as a simplified and convenient tool for calculating the arterial wall stresses in complex cases. Maximal stresses obtained by the 2D model with an asymmetric stenosis are lower than the maximal stresses obtained in the axisymmetric case with the same stenosis percentage. Therefore, axisymmetric models may provide the worst-case estimation values for a stent of interest.

Resumo Limpo

troduct restenosi strong attribut stress caus stentarteri interact generat arteri balloon angioplasti numer method often use examin stentarteri mechan interact overcom extens comput requir demand simul simplif neededobject introduc simplifi model calcul mechan interact netstructur stent arteri discuss valid implicationsmethod d simplifi numer model suggest allow cost effect assess arteri stress potenti damag factor df model sever contact problem solv arteri hyper elast mechan properti stress calcul larg rang case differ numer model type effect model simplif overs mismatch stenosi rate length symmetri result stress analyzedresult conclus result obtain planar d model found good agreement result obtain complex d model case axisymmetr constant vari stenosi high correl result d case vari stenosi simpl d case can use simplifi conveni tool calcul arteri wall stress complex case maxim stress obtain d model asymmetr stenosi lower maxim stress obtain axisymmetr case stenosi percentag therefor axisymmetr model may provid worstcas estim valu stent interest

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