Comput. Biol. Med. - Maxwell's equations-based dynamic laser-tissue interaction model.

Tópicos

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Resumo

Since its invention in the early 1960s, the laser has been used as a tool for surgical, therapeutic, and diagnostic purposes. To achieve maximum effectiveness with the greatest margin of safety it is important to understand the mechanisms of light propagation through tissue and how that light affects living cells. Lasers with novel output characteristics for medical and military applications are too often implemented prior to proper evaluation with respect to tissue optical properties and human safety. Therefore, advances in computational models that describe light propagation and the cellular responses to laser exposure, without the use of animal models, are of considerable interest. Here, a physics-based laser-tissue interaction model was developed to predict the dynamic changes in the spatial and temporal temperature rise during laser exposure to biological tissues. Unlike conventional models, the new approach is grounded on the rigorous electromagnetic theory that accounts for wave interference, polarization, and nonlinearity in propagation using a Maxwell's equations-based technique.

Resumo Limpo

sinc invent earli s laser use tool surgic therapeut diagnost purpos achiev maximum effect greatest margin safeti import understand mechan light propag tissu light affect live cell laser novel output characterist medic militari applic often implement prior proper evalu respect tissu optic properti human safeti therefor advanc comput model describ light propag cellular respons laser exposur without use anim model consider interest physicsbas lasertissu interact model develop predict dynam chang spatial tempor temperatur rise laser exposur biolog tissu unlik convent model new approach ground rigor electromagnet theori account wave interfer polar nonlinear propag use maxwel equationsbas techniqu

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