Comput. Biol. Med. - Numerical investigation of blood flow in three-dimensional porcine left anterior descending artery with various stenoses.

Tópicos

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Resumo

Coronary heart disease causes obstruction of coronary blood flow and is the leading cause of death worldwide. The effect of focal stenosis on downstream flow pattern in the coronary arterial tree is not well understood. Here, the blood flows in normal and diseased porcine left anterior descending (LAD) arterial tree were modeled and compared to determine the effects of stenosis on the blood flow distribution and hemodynamic parameters. The anatomical model of LAD was extracted from a porcine heart by computed tomography (CT), which was comprised of a main trunk and nine side branches. Stenoses with various severities were imposed into the main trunk between the first and second side branches, and the boundary condition at each outlet accounted for the effect of stenosis on the flow rate in the downstream vasculature. It was found that only significant stenosis (=75% area reduction) considerably altered pressure drop and total flow rate distribution in branches and at each bifurcation. The effect of significant stenosis on bifurcations, however, diminished at downstream locations. As demonstrated by distributions of oscillatory shear index and relative residence time, non-significant stenosis (<75% area reduction) has the potential to induce atherosclerosis near the ostium of downstream side branch, while significant stenosis can promote atherosclerosis in its wake.

Resumo Limpo

coronari heart diseas caus obstruct coronari blood flow lead caus death worldwid effect focal stenosi downstream flow pattern coronari arteri tree well understood blood flow normal diseas porcin left anterior descend lad arteri tree model compar determin effect stenosi blood flow distribut hemodynam paramet anatom model lad extract porcin heart comput tomographi ct compris main trunk nine side branch stenos various sever impos main trunk first second side branch boundari condit outlet account effect stenosi flow rate downstream vasculatur found signific stenosi area reduct consider alter pressur drop total flow rate distribut branch bifurc effect signific stenosi bifurc howev diminish downstream locat demonstr distribut oscillatori shear index relat resid time nonsignific stenosi area reduct potenti induc atherosclerosi near ostium downstream side branch signific stenosi can promot atherosclerosi wake

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