Comput. Biol. Med. - Computational gene network study on antibiotic resistance genes of Acinetobacter baumannii.

Tópicos

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Resumo

Multi Drug Resistance (MDR) in Acinetobacter baumannii is one of the major threats for emerging nosocomial infections in hospital environment. Multidrug-resistance in A. baumannii may be due to the implementation of multi-combination resistance mechanisms such as ?-lactamase synthesis, Penicillin-Binding Proteins (PBPs) changes, alteration in porin proteins and in efflux pumps against various existing classes of antibiotics. Multiple antibiotic resistance genes are involved in MDR. These resistance genes are transferred through plasmids, which are responsible for the dissemination of antibiotic resistance among Acinetobacter spp. In addition, these resistance genes may also have a tendency to interact with each other or with their gene products. Therefore, it becomes necessary to understand the impact of these interactions in antibiotic resistance mechanism. Hence, our study focuses on protein and gene network analysis on various resistance genes, to elucidate the role of the interacting proteins and to study their functional contribution towards antibiotic resistance. From the search tool for the retrieval of interacting gene/protein (STRING), a total of 168 functional partners for 15 resistance genes were extracted based on the confidence scoring system. The network study was then followed up with functional clustering of associated partners using molecular complex detection (MCODE). Later, we selected eight efficient clusters based on score. Interestingly, the associated protein we identified from the network possessed greater functional similarity with known resistance genes. This network-based approach on resistance genes of A. baumannii could help in identifying new genes/proteins and provide clues on their association in antibiotic resistance.

Resumo Limpo

multi drug resist mdr acinetobact baumannii one major threat emerg nosocomi infect hospit environ multidrugresist baumannii may due implement multicombin resist mechan lactamas synthesi penicillinbind protein pbps chang alter porin protein efflux pump various exist class antibiot multipl antibiot resist gene involv mdr resist gene transfer plasmid respons dissemin antibiot resist among acinetobact spp addit resist gene may also tendenc interact gene product therefor becom necessari understand impact interact antibiot resist mechan henc studi focus protein gene network analysi various resist gene elucid role interact protein studi function contribut toward antibiot resist search tool retriev interact geneprotein string total function partner resist gene extract base confid score system network studi follow function cluster associ partner use molecular complex detect mcode later select eight effici cluster base score interest associ protein identifi network possess greater function similar known resist gene networkbas approach resist gene baumannii help identifi new genesprotein provid clue associ antibiot resist

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