Comput. Biol. Med. - Computational study of particle size effects on selective binding of nanoparticles in arterial stenosis.

Tópicos

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Resumo

In order to elucidate particle size and wall shear effects on the selective binding of nanoparticles to vessel wall, particle binding to the wall of arterial stenosis was computationally analyzed using a transport and reaction model. The attachment rate constant was modeled as a function of shear rate and particle size. The results showed that it had a positive correlation with the shear rate for particles smaller than 600 nm and a negative correlation with the shear rate for particles larger than 800 nm. Small size particles showed high binding selectivity in the stenosis region for the normal and shear-activated wall, whereas large particles showed high binding selectivity in the low and oscillatory zone for the shear-activated wall.

Resumo Limpo

order elucid particl size wall shear effect select bind nanoparticl vessel wall particl bind wall arteri stenosi comput analyz use transport reaction model attach rate constant model function shear rate particl size result show posit correl shear rate particl smaller nm negat correl shear rate particl larger nm small size particl show high bind select stenosi region normal shearactiv wall wherea larg particl show high bind select low oscillatori zone shearactiv wall

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