Comput. Biol. Med. - First-principles modeling of fluid and solute exchange in the human during normal and hemodialysis conditions.

Tópicos

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{ model(2341) predict(2261) use(1141) }
{ model(3480) simul(1196) paramet(876) }
{ system(1976) rule(880) can(841) }
{ perform(999) metric(946) measur(919) }
{ cancer(2502) breast(956) screen(824) }
{ sequenc(1873) structur(1644) protein(1328) }
{ imag(2675) segment(2577) method(1081) }
{ treatment(1704) effect(941) patient(846) }
{ data(1714) softwar(1251) tool(1186) }
{ control(1307) perform(991) simul(935) }
{ visual(1396) interact(850) tool(830) }
{ blood(1257) pressur(1144) flow(957) }
{ patient(1821) servic(1111) care(1106) }
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{ system(1050) medic(1026) inform(1018) }
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{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
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{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ monitor(1329) mobil(1314) devic(1160) }
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{ patient(2837) hospit(1953) medic(668) }
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{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ can(981) present(881) function(850) }
{ high(1669) rate(1365) level(1280) }
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{ method(2212) result(1239) propos(1039) }

Resumo

A first-principles computer model of fluid and solute exchange under both physiological and hemodialysis condition is presented. The whole system has been modeled and simulated under the MODELICA integrated environment, which uses a hierarchical modeling strategy. The model performance has been analyzed by simulation in the light of existing hypothesis and physiological data used here for validation purposes. The results obtained provide a physiological interpretative key to patient's hemodynamic behavior during hemodialysis.

Resumo Limpo

firstprincipl comput model fluid solut exchang physiolog hemodialysi condit present whole system model simul modelica integr environ use hierarch model strategi model perform analyz simul light exist hypothesi physiolog data use valid purpos result obtain provid physiolog interpret key patient hemodynam behavior hemodialysi

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