Comput. Biol. Med. - Meta analysis of gene expression changes upon treatment of A549 cells with anti-cancer drugs to identify universal responses.

Tópicos

{ gene(2352) biolog(1181) express(1162) }
{ treatment(1704) effect(941) patient(846) }
{ drug(1928) target(777) effect(648) }
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{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ group(2977) signific(1463) compar(1072) }
{ data(3008) multipl(1320) sourc(1022) }
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Resumo

A meta-analysis of publicly available gene expression changes in A549 cells upon treatment with anti-cancer drugs is reported. To reduce false positives, both fold-change and significance level cutoffs were used. Simulated datasets and permutation analysis were used to guide choice of ratio cutoff. Of the genes identified, FDXR is the only gene differentially expressed in six of the seven drug treatments. Though FDXR has been reported to be differentially expressed upon treatment with 5-fluorouracil and its expression correlated to long term disease survival, to our knowledge this is a first study implicating a wide effect of anti-cancer drug treatment on FDXR expression. The other genes identified which are differentially expressed in four out of the seven drug treatments are CDKN1A and PARVB which are upregulated and MYC, HBP1, LDLR, SIM2, ALX1 and GPHN which are downregulated.

Resumo Limpo

metaanalysi public avail gene express chang cell upon treatment anticanc drug report reduc fals posit foldchang signific level cutoff use simul dataset permut analysi use guid choic ratio cutoff gene identifi fdxr gene differenti express six seven drug treatment though fdxr report differenti express upon treatment fluorouracil express correl long term diseas surviv knowledg first studi implic wide effect anticanc drug treatment fdxr express gene identifi differenti express four seven drug treatment cdkna parvb upregul myc hbp ldlr sim alx gphn downregul

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