Comput. Biol. Med. - Computer-aided techniques for chromogenic immunohistochemistry: status and directions.

Tópicos

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Resumo

Although immunohistochemistry (IHC) is a popular imaging technique, the quantitative analysis of IHC images via computer-aided methods is an emerging field that is gaining more and more importance thanks to the new developments in digital high-throughput scanners. In this paper, we discuss the main steps of IHC and review the techniques for computer-aided chromogenic IHC analysis, including methods to determine the location of interest of the antigens and quantify their activations. Moreover, we discuss the issues arising from the standardization of the immunostaining process, that are generally overlooked by the current literature, and finally provide requirements for reliable computer-aided IHC quantification.

Resumo Limpo

although immunohistochemistri ihc popular imag techniqu quantit analysi ihc imag via computeraid method emerg field gain import thank new develop digit highthroughput scanner paper discuss main step ihc review techniqu computeraid chromogen ihc analysi includ method determin locat interest antigen quantifi activ moreov discuss issu aris standard immunostain process general overlook current literatur final provid requir reliabl computeraid ihc quantif

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