Comput. Biol. Med. - The association of CD28 polymorphism, rs3116496, with Cancer: A meta-analysis.

Tópicos

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Resumo

JECTIVE: To determine the relationship between CD28 polymorphisms, rs3116496, and cancer.DESIGN: Meta-analysis.METHODS: PubMed, EMBASE, Web of Science, and Cochrane library databases were searched to identify studies reporting the association between CD28 polymorphism and cancer. Two authors selected identified studies, extracted, and analyzed the data independently.RESULTS: Individuals carrying a T allele (TT homozygotes and TT+TC heterozygotes) at rs3116496 had a lower incidence of cancer than carriers of a C allele. Subgroup analysis showed that this association held true for Asians, but not Europeans.CONCLUSION: CD28 polymorphism, rs3116496, contributes to cancer susceptibility in the case of multiple cancers.

Resumo Limpo

jectiv determin relationship cd polymorph rs cancerdesign metaanalysismethod pubm embas web scienc cochran librari databas search identifi studi report associ cd polymorph cancer two author select identifi studi extract analyz data independentlyresult individu carri t allel tt homozygot tttc heterozygot rs lower incid cancer carrier c allel subgroup analysi show associ held true asian europeansconclus cd polymorph rs contribut cancer suscept case multipl cancer

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