Comput. Biol. Med. - Blood glucose level reconstruction as a function of transcapillary glucose transport.


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A diabetic patient occasionally undergoes a detailed monitoring of their glucose levels. Over the course of a few days, a monitoring system provides a detailed track of their interstitial fluid glucose levels measured in their subcutaneous tissue. A discrepancy in the blood and interstitial fluid glucose levels is unimportant because the blood glucose levels are not measured continuously. Approximately five blood glucose level samples are taken per day, and the interstitial fluid glucose level is usually measured every 5min. An increased frequency of blood glucose level sampling would cause discomfort for the patient; thus, there is a need for methods to estimate blood glucose levels from the glucose levels measured in subcutaneous tissue. The Steil-Rebrin model is widely used to describe the relationship between blood and interstitial fluid glucose dynamics. However, we measured glucose level patterns for which the Steil-Rebrin model does not hold. Therefore, we based our research on a different model that relates present blood and interstitial fluid glucose levels to future interstitial fluid glucose levels. Using this model, we derived an improved model for calculating blood glucose levels. In the experiments conducted, this model outperformed the Steil-Rebrin model while introducing no additional requirements for glucose sample collection. In subcutaneous tissue, 26.71% of the calculated blood glucose levels had absolute values of relative differences from smoothed measured blood glucose levels less than or equal to 5% using the Steil-Rebrin model. However, the same difference interval was encountered in 63.01% of the calculated blood glucose levels using the proposed model. In addition, 79.45% of the levels calculated with the Steil-Rebrin model compared with 95.21% of the levels calculated with the proposed model had 20% difference intervals.

Resumo Limpo

diabet patient occasion undergo detail monitor glucos level cours day monitor system provid detail track interstiti fluid glucos level measur subcutan tissu discrep blood interstiti fluid glucos level unimport blood glucos level measur continu approxim five blood glucos level sampl taken per day interstiti fluid glucos level usual measur everi min increas frequenc blood glucos level sampl caus discomfort patient thus need method estim blood glucos level glucos level measur subcutan tissu steilrebrin model wide use describ relationship blood interstiti fluid glucos dynam howev measur glucos level pattern steilrebrin model hold therefor base research differ model relat present blood interstiti fluid glucos level futur interstiti fluid glucos level use model deriv improv model calcul blood glucos level experi conduct model outperform steilrebrin model introduc addit requir glucos sampl collect subcutan tissu calcul blood glucos level absolut valu relat differ smooth measur blood glucos level less equal use steilrebrin model howev differ interv encount calcul blood glucos level use propos model addit level calcul steilrebrin model compar level calcul propos model differ interv

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