Comput. Biol. Med. - OvaSpec - A vision-based instrument for assessing concentration and developmental stage of Trichuris suis parasite egg suspensions.

Tópicos

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Resumo

CKGROUND: OvaSpec is a new, fully automated, vision-based instrument for assessing the quantity (concentration) and quality (embryonation percentage) of Trichuris suis parasite eggs in liquid suspension. The eggs constitute the active pharmaceutical ingredient in a medicinal drug for the treatment of immune-mediated diseases such as Crohns disease, ulcerative colitis, and multiple sclerosis.METHODS: This paper describes the development of an automated microscopy technology, including methodological challenges and design decisions of relevance for the future development of comparable vision-based instruments. Morphological properties are used to distinguish eggs from impurities and two features of the egg contents under brightfield and darkfield illumination are used in a statistical classification to distinguish eggs with undifferentiated contents (non-embryonated eggs) from eggs with fully developed larvae inside (embryonated eggs).RESULTS: For assessment of the instruments performance, six egg suspensions of varying quality were used to generate a dataset of unseen images. Subsequently, annotation of the detected eggs and impurities revealed a high agreement with the manual, image-based assessments for both concentration and embryonation percentage (both error rates <1.0%). Similarly, a strong correlation was demonstrated in a final, blinded comparison with traditional microscopic assessments performed by an experienced laboratory technician.CONCLUSIONS: The present study demonstrates the applicability of computer vision in the production, analysis, and quality control of T. suis eggs used as an active pharmaceutical ingredient for the treatment of autoimmune diseases.

Resumo Limpo

ckground ovaspec new fulli autom visionbas instrument assess quantiti concentr qualiti embryon percentag trichuri sui parasit egg liquid suspens egg constitut activ pharmaceut ingredi medicin drug treatment immunemedi diseas crohn diseas ulcer coliti multipl sclerosismethod paper describ develop autom microscopi technolog includ methodolog challeng design decis relev futur develop compar visionbas instrument morpholog properti use distinguish egg impur two featur egg content brightfield darkfield illumin use statist classif distinguish egg undifferenti content nonembryon egg egg fulli develop larva insid embryon eggsresult assess instrument perform six egg suspens vari qualiti use generat dataset unseen imag subsequ annot detect egg impur reveal high agreement manual imagebas assess concentr embryon percentag error rate similar strong correl demonstr final blind comparison tradit microscop assess perform experienc laboratori technicianconclus present studi demonstr applic comput vision product analysi qualiti control t sui egg use activ pharmaceut ingredi treatment autoimmun diseas

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