Comput. Biol. Med. - An automatic tool to facilitate the statistical group analysis of DTI.


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CKGROUND: Users may have difficulty calculating DTI group statistics since they need to master several complex tools that require high user intervention. A tool called DTIStatistics for the automatic and easy calculation of DTI group statistics was developed to reduce analysis times and possible errors.METHODS: The proposed software was designed by using a user-centred methodology in which we performed an iterative usability evaluation with an expert committee. Once the experts requirements were fulfilled, we performed a validation of the final version of DTIStatistics with target users, comparing the execution time of this tool and the standard pipeline normally used.RESULTS: Target users needed significantly less time to complete the tasks with DTIStatistics, reducing the analysis time from 1383.78 to 57.2s. They were able to complete all the tasks and barely made errors. Moreover, target users were not able to display the analysis results with the standard pipeline, but when using our tool they only needed 34s. Target users found DTIStatistics easy to learn, use and interact with, and they concluded that they could effectively complete the tasks with it. Additionally, we present example results in the study of depression to demonstrate the validity of DTIStatistics for clinical research.CONCLUSIONS: DTIStatistics facilitates and significantly automates the calculation of DTI group statistics by reducing the analysis times, which implies lower costs. DTIStatistics is highly applicable in clinical research, as demonstrated by the fact that it is currently being used at the University Hospital, University of Navarra (Spain).

Resumo Limpo

ckground user may difficulti calcul dti group statist sinc need master sever complex tool requir high user intervent tool call dtistatist automat easi calcul dti group statist develop reduc analysi time possibl errorsmethod propos softwar design use usercentr methodolog perform iter usabl evalu expert committe expert requir fulfil perform valid final version dtistatist target user compar execut time tool standard pipelin normal usedresult target user need signific less time complet task dtistatist reduc analysi time s abl complet task bare made error moreov target user abl display analysi result standard pipelin use tool need s target user found dtistatist easi learn use interact conclud effect complet task addit present exampl result studi depress demonstr valid dtistatist clinic researchconclus dtistatist facilit signific autom calcul dti group statist reduc analysi time impli lower cost dtistatist high applic clinic research demonstr fact current use univers hospit univers navarra spain

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