Comput. Biol. Med. - Predicting miRNA-mediated gene silencing mode based on miRNA-target duplex features.

Tópicos

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{ detect(2391) sensit(1101) algorithm(908) }

Resumo

There are two main mechanisms of miRNA-mediated gene silencing: either mRNA degradation or translational repression. However, the precise mechanism of target mRNAs regulated by miRNA remains unclear. As a complementary approach to experiment, a computational method was proposed to recognize the mechanism of miRNA-mediated gene silencing in human. We have analyzed extensive features correlated with miRNA-mediated silencing mechanism of mRNA. It is found that, the duplex structure, the number of binding sites and the structural accessibility of target site region are effective factors in determining whether a target mRNA is cleaved or only translationally inhibited. An SVM-based classifier was constructed to predict the regulation mode of miRNA based on these informative features. The results indicated that the approach proposed is effective in distinguishing whether a target mRNA is cleaved or translationally inhibited in human. Furthermore, the web server microDoR (http://reprod.njmu.edu.cn/microdor) has been developed and is freely available for users.

Resumo Limpo

two main mechan mirnamedi gene silenc either mrna degrad translat repress howev precis mechan target mrnas regul mirna remain unclear complementari approach experi comput method propos recogn mechan mirnamedi gene silenc human analyz extens featur correl mirnamedi silenc mechan mrna found duplex structur number bind site structur access target site region effect factor determin whether target mrna cleav translat inhibit svmbase classifi construct predict regul mode mirna base inform featur result indic approach propos effect distinguish whether target mrna cleav translat inhibit human furthermor web server microdor httpreprodnjmueducnmicrodor develop freeli avail user

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