Comput. Biol. Med. - Cellular oncomiR orthologue in EBV oncogenesis.

Tópicos

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Resumo

MicroRNAs are small non-coding RNAs that regulate gene expression at multiple levels. The discovery of virally encoded miRNAs attracted immense attention towards their role in viral replication and pathogenesis. Kaposi's-sarcoma-associated herpes virus encodes miRNA that functions as an orthologue of human cellular miRNA, i.e., hsa-miR-155. Keeping the same view we extended the miRNA-homology search between the miRNAs of humans and Epstein-Barr virus. The In silico analyses shows that EBV encoded miR-BART-5 has a significant 'seed' sequence homology to hsa-miR-18 of humans. Further, the mRNA transcripts of the human genes involved in cellular growth could potentially be targeted by both viral as well as human miRNAs. The known etiological role of hsa-miR-18 as an oncomiR suggests that miR-BART-5 may function as viral oncomiR as observed in EBV-positive gastric carcinoma patients.

Resumo Limpo

microrna small noncod rnas regul gene express multipl level discoveri viral encod mirna attract immens attent toward role viral replic pathogenesi kaposissarcomaassoci herp virus encod mirna function orthologu human cellular mirna ie hsamir keep view extend mirnahomolog search mirna human epsteinbarr virus silico analys show ebv encod mirbart signific seed sequenc homolog hsamir human mrna transcript human gene involv cellular growth potenti target viral well human mirna known etiolog role hsamir oncomir suggest mirbart may function viral oncomir observ ebvposit gastric carcinoma patient

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