Comput. Biol. Med. - Experimental validation of 3D printed patient-specific implants using digital image correlation and finite element analysis.


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With the dawn of 3D printing technology, patient-specific implant designs are set to have a paradigm shift. A topology optimization method in designing patient-specific craniofacial implants has been developed to ensure adequate load transfer mechanism and restore the form and function of the mid-face. Patient-specific finite element models are used to design these implants and to validate whether they are viable for physiological loading such as mastication. Validation of these topology optimized finite element models using mechanical testing is a critical step. Instead of inserting the implants into a cadaver or patient, we embed the implants into the computer-aided skull model of a patient and, fuse them together to 3D print the complete skull model with the implant. Masticatory forces are applied in the molar region to simulate chewing and measure the stress-strain trajectory. Until recently, strain gages have been used to measure strains for validation. Digital Image Correlation (DIC) method is a relatively new technique for full-field strain measurement which provides a continuous deformation field data. The main objective of this study is to validate the finite element model of patient-specific craniofacial implants against the strain data from the DIC obtained during the mastication simulation and show that the optimized shapes provide adequate load-transfer mechanism. Patient-specific models are obtained from CT scans. The principal maximum and minimum strains are compared. The computational and experimental approach to designing patient-specific implants proved to be a viable technique for mid-face craniofacial reconstruction.

Resumo Limpo

dawn d print technolog patientspecif implant design set paradigm shift topolog optim method design patientspecif craniofaci implant develop ensur adequ load transfer mechan restor form function midfac patientspecif finit element model use design implant valid whether viabl physiolog load mastic valid topolog optim finit element model use mechan test critic step instead insert implant cadav patient emb implant computeraid skull model patient fuse togeth d print complet skull model implant masticatori forc appli molar region simul chew measur stressstrain trajectori recent strain gage use measur strain valid digit imag correl dic method relat new techniqu fullfield strain measur provid continu deform field data main object studi valid finit element model patientspecif craniofaci implant strain data dic obtain mastic simul show optim shape provid adequ loadtransf mechan patientspecif model obtain ct scan princip maximum minimum strain compar comput experiment approach design patientspecif implant prove viabl techniqu midfac craniofaci reconstruct

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