Comput. Biol. Med. - Mathematical modeling and sensitivity analysis of the integrated TNFa-mediated apoptotic pathway for identifying key regulators.

Tópicos

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Resumo

TNFa-mediated apoptosis is one of the complex and tightly regulated cellular processes as it involves the activation of both pro- and anti-apoptotic signaling pathways. Thus, it is important to elucidate the molecular players of this process and their dynamics in order to gain an in-depth understanding of the mechanisms underlying apoptosis. To this end, we proposed an integrated model of TNFa-mediated apoptosis pathway in Type I cells, formulated based on the principles of mass action kinetics. The model includes major apoptotic modules-the extrinsic and intrinsic pathways, the NFB survival signaling and various regulatory mechanisms. We performed simulations and sensitivity analyses to study the role of NFB pathway in regulating apoptosis, and identified IAP as one of the more potent regulators of apoptosis.

Resumo Limpo

tnfamedi apoptosi one complex tight regul cellular process involv activ pro antiapoptot signal pathway thus import elucid molecular player process dynam order gain indepth understand mechan under apoptosi end propos integr model tnfamedi apoptosi pathway type cell formul base principl mass action kinet model includ major apoptot modulesth extrins intrins pathway nfb surviv signal various regulatori mechan perform simul sensit analys studi role nfb pathway regul apoptosi identifi iap one potent regul apoptosi

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