Comput. Biol. Med. - Identification of voltage-gated potassium channel subfamilies from sequence information using support vector machine.

Tópicos

{ learn(2355) train(1041) set(1003) }
{ imag(1947) propos(1133) code(1026) }
{ featur(3375) classif(2383) classifi(1994) }
{ signal(2180) analysi(812) frequenc(800) }
{ sequenc(1873) structur(1644) protein(1328) }
{ algorithm(1844) comput(1787) effici(935) }
{ perform(1367) use(1326) method(1137) }
{ can(774) often(719) complex(702) }
{ can(981) present(881) function(850) }
{ use(976) code(926) identifi(902) }
{ method(2212) result(1239) propos(1039) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ high(1669) rate(1365) level(1280) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ method(1219) similar(1157) match(930) }
{ model(2341) predict(2261) use(1141) }
{ compound(1573) activ(1297) structur(1058) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ sampl(1606) size(1419) use(1276) }
{ first(2504) two(1366) second(1323) }
{ health(1844) social(1437) communiti(874) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ implement(1333) system(1263) develop(1122) }
{ decis(3086) make(1611) patient(1517) }
{ model(3404) distribut(989) bayesian(671) }
{ data(1737) use(1416) pattern(1282) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ chang(1828) time(1643) increas(1301) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ extract(1171) text(1153) clinic(932) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ import(1318) role(1303) understand(862) }
{ visual(1396) interact(850) tool(830) }
{ studi(1119) effect(1106) posit(819) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ analysi(2126) use(1163) compon(1037) }
{ structur(1116) can(940) graph(676) }
{ cancer(2502) breast(956) screen(824) }
{ result(1111) use(1088) new(759) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Proteins belonging to different subfamilies of Voltage-gated K(+) channels (VKC) are functionally divergent. The traditional method to classify ion channels is more time consuming. Thus, it is highly desirable to develop novel computational methods for VKC subfamily classification. In this study, a support vector machine based method was proposed to predict VKC subfamilies using amino acid and dipeptide compositions. In order to remove redundant information, a novel feature selection technique was employed to single out optimized features. In the jackknife cross-validation, the proposed method (VKCPred) achieved an overall accuracy of 93.09% with 93.22% average sensitivity and 98.34% average specificity, which are superior to that of other two state-of-the-art classifiers. These results indicate that VKCPred can be efficiently used to identify and annotate voltage-gated K(+) channels' subfamilies. The VKCPred software and dataset are freely available at http://cobi.uestc.edu.cn/people/hlin/tools/VKCPred/.

Resumo Limpo

protein belong differ subfamili voltageg k channel vkc function diverg tradit method classifi ion channel time consum thus high desir develop novel comput method vkc subfamili classif studi support vector machin base method propos predict vkc subfamili use amino acid dipeptid composit order remov redund inform novel featur select techniqu employ singl optim featur jackknif crossvalid propos method vkcpred achiev overal accuraci averag sensit averag specif superior two stateoftheart classifi result indic vkcpred can effici use identifi annot voltageg k channel subfamili vkcpred softwar dataset freeli avail httpcobiuestceducnpeoplehlintoolsvkcpr

Resumos Similares

Int J Neural Syst - Epileptic EEG classification based on kernel sparse representation. ( 0,751529475121262 )
J. Comput. Biol. - Computing the probability of RNA hairpin and multiloop formation. ( 0,664837487872527 )
Med Biol Eng Comput - Classification of multichannel EEG patterns using parallel hidden Markov models. ( 0,649007191796392 )
Artif Intell Med - A fuzzy-based data transformation for feature extraction to increase classification performance with small medical data sets. ( 0,643889727749446 )
AMIA Annu Symp Proc - A discriminative approach to EEG seizure detection. ( 0,640893759327403 )
IEEE Trans Image Process - Compressive sensing via nonlocal low-rank regularization. ( 0,63816575465728 )
IEEE Trans Image Process - Learning discriminative dictionary for group sparse representation. ( 0,635648120782104 )
J Chem Inf Model - Classifying large chemical data sets: using a regularized potential function method. ( 0,632021656631618 )
Comput. Biol. Med. - Medical decision support system for diagnosis of neuromuscular disorders using DWT and fuzzy support vector machines. ( 0,629393610492191 )
Comput. Biol. Med. - Remote protein homology detection and fold recognition using two-layer support vector machine classifiers. ( 0,628751177572976 )
Comput Methods Programs Biomed - Clustering technique-based least square support vector machine for EEG signal classification. ( 0,626596932767092 )
IEEE J Biomed Health Inform - Multiple kernel learning in the primal for multimodal Alzheimer's disease classification. ( 0,624318077735104 )
Comput. Biol. Med. - Relabeling algorithm for retrieval of noisy instances and improving prediction quality. ( 0,623182385808841 )
IEEE Trans Image Process - Active learning for solving the incomplete data problem in facial age classification by the furthest nearest-neighbor criterion. ( 0,619282464817202 )
Comput Biol Chem - Prediction of protein modification sites of gamma-carboxylation using position specific scoring matrices based evolutionary information. ( 0,618484809390284 )
IEEE Trans Image Process - Multiple-kernel, multiple-instance similarity features for efficient visual object detection. ( 0,612538044708665 )
J Am Med Inform Assoc - Missing values in deduplication of electronic patient data. ( 0,602099720863812 )
Artif Intell Med - Kernel machines for epilepsy diagnosis via EEG signal classification: a comparative study. ( 0,599811856533185 )
IEEE J Biomed Health Inform - Exploiting prior knowledge in compressed sensing wireless ECG systems. ( 0,598975243348391 )
Comput. Biol. Med. - Sparse Manifold Clustering and Embedding to discriminate gene expression profiles of glioblastoma and meningioma tumors. ( 0,598270770119623 )
IEEE Trans Image Process - A sparse embedding and least variance encoding approach to hashing. ( 0,59791136812459 )
IEEE Trans Neural Netw Learn Syst - A Novel Empirical Mode Decomposition With Support Vector Regression for Wind Speed Forecasting. ( 0,592882155443582 )
IEEE Trans Neural Netw Learn Syst - Adaptive Batch Mode Active Learning. ( 0,588386473158694 )
Artif Intell Med - Supervised machine learning-based classification of oral malodor based on the microbiota in saliva samples. ( 0,586912823595448 )
IEEE Trans Pattern Anal Mach Intell - A Bag-of-Features Framework to Classify Time Series. ( 0,584712582612211 )
Med Biol Eng Comput - Efficient automatic classifiers for the detection of A phases of the cyclic alternating pattern in sleep. ( 0,58425626369127 )
Comput Methods Programs Biomed - Modified CC-LR algorithm with three diverse feature sets for motor imagery tasks classification in EEG based brain-computer interface. ( 0,581488241572871 )
Neural Comput - Deep, big, simple neural nets for handwritten digit recognition. ( 0,581457189389264 )
IEEE J Biomed Health Inform - Automatic detection of atrial fibrillation in cardiac vibration signals. ( 0,580135505703846 )
Neural Comput - Feature selection for ordinal text classification. ( 0,579673928818176 )
Comput Math Methods Med - Dimensionality reduction by supervised neighbor embedding using laplacian search. ( 0,57894224877061 )
IEEE Trans Pattern Anal Mach Intell - Feature Selection with Conjunctions of Decision Stumps and Learning from Microarray Data. ( 0,57782150265366 )
IEEE Trans Image Process - Simplified 2-D cubic spline interpolation scheme using direct computation algorithm. ( 0,576441859376095 )
Med Biol Eng Comput - SEMG-based hand motion recognition using cumulative residual entropy and extreme learning machine. ( 0,57488305242787 )
Neural Comput - Adaptive metric learning vector quantization for ordinal classification. ( 0,574484741216915 )
J Med Syst - An automatic fuzzy-based multi-temporal brain digital subtraction angiography image fusion algorithm using curvelet transform and content selection strategy. ( 0,574340110047539 )
Med Biol Eng Comput - Wavelet-based sparse functional linear model with applications to EEGs seizure detection and epilepsy diagnosis. ( 0,571742109839197 )
BMC Med Inform Decis Mak - Using n-gram analysis to cluster heartbeat signals. ( 0,57043949502778 )
Artif Intell Med - Transductive domain adaptive learning for epileptic electroencephalogram recognition. ( 0,570357471959881 )
IEEE Trans Pattern Anal Mach Intell - Distance-Based Image Classification: Generalizing to New Classes at Near Zero Cost. ( 0,569566566476414 )
J Am Med Inform Assoc - A sequence labeling approach to link medications and their attributes in clinical notes and clinical trial announcements for information extraction. ( 0,569432190614093 )
J Med Syst - Super wavelet for sEMG signal extraction during dynamic fatiguing contractions. ( 0,569228945541814 )
J Med Syst - Automated screening of arrhythmia using wavelet based machine learning techniques. ( 0,567883839940117 )
IEEE Trans Pattern Anal Mach Intell - Learning Hierarchical Features for Scene Labeling. ( 0,567317287421708 )
Neural Comput - Multilabel classification with principal label space transformation. ( 0,565496776383676 )
J Chem Inf Model - A binary ant colony optimization classifier for molecular activities. ( 0,56182245370813 )
Artif Intell Med - Screening nonrandomized studies for medical systematic reviews: a comparative study of classifiers. ( 0,56134823284312 )
Med Biol Eng Comput - Spatio-spectral filters for low-density surface electromyographic signal classification. ( 0,558871560408179 )
BMC Med Inform Decis Mak - Predicting disease risks from highly imbalanced data using random forest. ( 0,558197593982719 )
Comput. Biol. Med. - A learning method for the class imbalance problem with medical data sets. ( 0,557587628676834 )
J Am Med Inform Assoc - Applying active learning to supervised word sense disambiguation in MEDLINE. ( 0,555150744719348 )
Comput Biol Chem - Support vector machine with a Pearson VII function kernel for discriminating halophilic and non-halophilic proteins. ( 0,555030276704441 )
Int J Neural Syst - Aggregation of sparse linear discriminant analyses for event-related potential classification in brain-computer interface. ( 0,55306900938413 )
Comput Methods Programs Biomed - A machine learning approach to multi-level ECG signal quality classification. ( 0,552802832243855 )
Comput. Biol. Med. - Robust prediction of protein subcellular localization combining PCA and WSVMs. ( 0,552202865736864 )
Comput. Biol. Med. - Classification of EMG signals using PSO optimized SVM for diagnosis of neuromuscular disorders. ( 0,551834797046472 )
Comput Methods Programs Biomed - Compressed sampling for heart rate monitoring. ( 0,551552529773078 )
IEEE Trans Image Process - Efficient HIK SVM learning for image classification. ( 0,55127935171493 )
J Med Syst - Diagnosis of several diseases by using combined kernels with Support Vector Machine. ( 0,55041414425895 )
Neural Comput - Divergence-based vector quantization. ( 0,548891657143786 )
J. Comput. Biol. - The irredundant class method for remote homology detection of protein sequences. ( 0,548839687043964 )
IEEE Trans Image Process - A Probabilistic Associative Model for Segmenting Weakly-Supervised Images. ( 0,547267233169888 )
IEEE Trans Pattern Anal Mach Intell - Cross-sensor Iris Recognition through Kernel Learning. ( 0,54650002611833 )
Comput. Biol. Med. - EEG-based emotion estimation using Bayesian weighted-log-posterior function and perceptron convergence algorithm. ( 0,545843061643773 )
Comput Methods Programs Biomed - Discriminating protein structure classes by incorporating Pseudo Average Chemical Shift to Chou's general PseAAC and Support Vector Machine. ( 0,544285000844429 )
IEEE Trans Neural Netw Learn Syst - Ordinal Distance Metric Learning for Image Ranking. ( 0,543503460334901 )
IEEE Trans Image Process - Learning conditional random fields for classification of hyperspectral images. ( 0,542997024538986 )
Comput. Biol. Med. - Identification of epilepsy stages from ECoG using genetic programming classifiers. ( 0,542321453664764 )
J Chem Inf Model - In silico prediction of chemical acute oral toxicity using multi-classification methods. ( 0,54180814020965 )
J Med Syst - 3D similarity-dissimilarity plot for high dimensional data visualization in the context of biomedical pattern classification. ( 0,541626778836789 )
J Chem Inf Model - Classifying molecules using a sparse probabilistic kernel binary classifier. ( 0,540805099926507 )
J Integr Bioinform - On the parameter optimization of Support Vector Machines for binary classification. ( 0,540450938300908 )
Neural Comput - Computing sparse representations of multidimensional signals using Kronecker bases. ( 0,539709846668071 )
J Biomed Inform - Applying active learning to assertion classification of concepts in clinical text. ( 0,538548457029946 )
Artif Intell Med - Conversational case-based reasoning in medical decision making. ( 0,536728010791763 )
Comput Methods Programs Biomed - Supervised hybrid feature selection based on PSO and rough sets for medical diagnosis. ( 0,536156309582479 )
Int J Neural Syst - Linear time relational prototype based learning. ( 0,534661020810272 )
IEEE Trans Neural Netw Learn Syst - Evolutionary fuzzy ARTMAP neural networks for classification of semiconductor defects. ( 0,533767118589685 )
Comput Methods Programs Biomed - Complex extreme learning machine applications in terahertz pulsed signals feature sets. ( 0,53360704817472 )
IEEE Trans Pattern Anal Mach Intell - Label Consistent K-SVD: Learning A Discriminative Dictionary for Recognition. ( 0,53263977932327 )
Comput Biol Chem - CE-PLoc: an ensemble classifier for predicting protein subcellular locations by fusing different modes of pseudo amino acid composition. ( 0,532075059846603 )
Int J Neural Syst - Span: spike pattern association neuron for learning spatio-temporal spike patterns. ( 0,531550579976135 )
J Biomed Inform - A medical diagnostic tool based on radial basis function classifiers and evolutionary simulated annealing. ( 0,531123664615661 )
BMC Med Inform Decis Mak - Efficient techniques for genotype-phenotype correlational analysis. ( 0,530814840285782 )
IEEE Trans Image Process - Absolute depth estimation from a single defocused image. ( 0,530373847440232 )
Med Biol Eng Comput - Robust extraction of P300 using constrained ICA for BCI applications. ( 0,52972125632108 )
IEEE Trans Neural Netw Learn Syst - ML-Tree: a tree-structure-based approach to multilabel learning. ( 0,529700454938338 )
Comput Methods Programs Biomed - A new wavelet transform to sparsely represent cortical current densities for EEG/MEG inverse problems. ( 0,52829253151861 )
IEEE Trans Image Process - Compressive sensing by learning a Gaussian mixture model from measurements. ( 0,52722886678394 )
IEEE Trans Vis Comput Graph - Exploring the Spectrum of Dynamic Scheduling Algorithms for Scalable Distributed-Memory Ray Tracing. ( 0,526878874792173 )
Comput Math Methods Med - Fast discriminative stochastic neighbor embedding analysis. ( 0,526546469776527 )
Comput Math Methods Med - Identifying patients with poststroke mild cognitive impairment by pattern recognition of working memory load-related ERP. ( 0,52576946464649 )
J Med Syst - A software framework for building biomedical machine learning classifiers through grid computing resources. ( 0,525655020774681 )
IEEE Trans Pattern Anal Mach Intell - Latent Dirichlet Allocation Models for Image Classification. ( 0,525641025641026 )
IEEE Trans Image Process - Improving Web image search by bag-based reranking. ( 0,525575623028476 )
J Clin Monit Comput - Heart rate variability analysis during central hypovolemia using wavelet transformation. ( 0,524515283833397 )
J Chem Inf Model - Atom environment kernels on molecules. ( 0,523538469602051 )
J Clin Monit Comput - Identification of apnea during respiratory monitoring using support vector machine classifier: a pilot study. ( 0,522818546596661 )
Int J Neural Syst - Improved adaptive splitting and selection: the hybrid training method of a classifier based on a feature space partitioning. ( 0,522609761683093 )
AMIA Annu Symp Proc - Predicting discharge mortality after acute ischemic stroke using balanced data. ( 0,522257492179388 )