Comput. Biol. Med. - Complex activity patterns in arterial wall: results from a model of calcium dynamics.

Tópicos

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Resumo

Using a dynamical model of smooth muscle cells in an arterial wall, defined as a system of coupled five-dimensional nonlinear oscillators, on a grid with cylindrical symmetry, we compare the admissible activity patterns with those known from the heart tissue. We postulate on numerical basis the possibility to induce a stable spiral wave in the arterial wall. Such a spiral wave can inhibit the propagation of the axial calcium wave and effectively stop the vasomotion. We also discuss the dynamics of the circumferential calcium wave in comparison to rotors in venous ostia that are a common source of supraventricular ectopy. We show that the velocity and in consequence the frequency range of the circumferential calcium wave is by orders of magnitude too small compared to that of the rotors. The mechanism of the rotor is not likely to involve the calcium-related dynamics of the smooth muscle cells. The calcium-related dynamics which is voltage-independent and hard to be reset seems to actually protect the blood vessels against the electric activity of the atria. We also discuss the microreentry phenomenon, which was found in numerical experiments in the studied model.

Resumo Limpo

use dynam model smooth muscl cell arteri wall defin system coupl fivedimension nonlinear oscil grid cylindr symmetri compar admiss activ pattern known heart tissu postul numer basi possibl induc stabl spiral wave arteri wall spiral wave can inhibit propag axial calcium wave effect stop vasomot also discuss dynam circumferenti calcium wave comparison rotor venous ostia common sourc supraventricular ectopi show veloc consequ frequenc rang circumferenti calcium wave order magnitud small compar rotor mechan rotor like involv calciumrel dynam smooth muscl cell calciumrel dynam voltageindepend hard reset seem actual protect blood vessel electr activ atria also discuss microreentri phenomenon found numer experi studi model

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