Comput. Biol. Med. - Modeling of tumor growth undergoing virotherapy.

Tópicos

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Resumo

Tumor growth models subject to virotherapy treatment are analyzed and compared in this paper. Tumor growth conditions are obtained for each model type based on the virus infection rate and immune suppressive drug delivery. Equilibrium conditions resulted into quadratic functions for which the tumor radius remained constant during virotherapy. An irrigation tumor model for virotherapy treatment was also proposed. This model consists of irrigation layers distributed radially along the tumor and attached to a common blood circulation compartment. The irrigation model has similar dynamic and steady state characteristics to the diffusion model, which has been supported by experimental results. The irrigation model considers the immune system cell generation and consumption outside the tumor boundary but inside the blood circulation compartment. These characteristics provide a great potential for advanced cancer treatment applications because therapy dose delivery and immune system measurements can be made at the blood compartment level of the irrigation model.

Resumo Limpo

tumor growth model subject virotherapi treatment analyz compar paper tumor growth condit obtain model type base virus infect rate immun suppress drug deliveri equilibrium condit result quadrat function tumor radius remain constant virotherapi irrig tumor model virotherapi treatment also propos model consist irrig layer distribut radial along tumor attach common blood circul compart irrig model similar dynam steadi state characterist diffus model support experiment result irrig model consid immun system cell generat consumpt outsid tumor boundari insid blood circul compart characterist provid great potenti advanc cancer treatment applic therapi dose deliveri immun system measur can made blood compart level irrig model

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