AMIA Annu Symp Proc - Use of standard drug vocabularies in clinical research: a case study in pediatrics.

Tópicos

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Resumo

Clinical and epidemiological researchers across all medical specialties need tools and knowledge representations to support the classification, aggregation, and analysis of medication data. The Veterans Affairs National Drug File Reference Terminology (NDF-RT) is a named standard for classifying medications. We describe our experience applying NDF-RT to aggregate RxNorm-encoded medications that were collected from an international cohort of over 8,000 children. We detail the researchers' analysis objectives and subsequent requirements for a drug classification representation, and assess the ability of NDF-RT to provide classes that are meaningful to pediatric researchers. In addition, we explore the completeness of RxNorm - NDF-RT mappings (i.e., the coverage of NDF-RT) for this sample of pediatric medications. We conclude that NDF-RT is sufficient to address the knowledge representation needs for this research study, though only a small subset of NDF-RT is needed for research analyses. Researchers from all domains would benefit from tools for easily extracting a set of relevant classes from the NDF-RT knowledge structure.

Resumo Limpo

clinic epidemiolog research across medic specialti need tool knowledg represent support classif aggreg analysi medic data veteran affair nation drug file refer terminolog ndfrt name standard classifi medic describ experi appli ndfrt aggreg rxnormencod medic collect intern cohort children detail research analysi object subsequ requir drug classif represent assess abil ndfrt provid class meaning pediatr research addit explor complet rxnorm ndfrt map ie coverag ndfrt sampl pediatr medic conclud ndfrt suffici address knowledg represent need research studi though small subset ndfrt need research analys research domain benefit tool easili extract set relev class ndfrt knowledg structur

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